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Article

Early Alterations of QTc in Patients with COVID-19 Treated with Hydroxychloroquine or Chloroquine in Libreville, Gabon

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Cardiology Department, University Hospital of Libreville, Libreville P.O. Box 18231, Gabon
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Department of Medicine, University Hospital of Libreville, Libreville P.O. Box 18231, Gabon
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Department of Basic Sciences, Faculty of Medicine, Université des Sciences de la Santé, Libreville BP 4009, Gabon
*
Author to whom correspondence should be addressed.
Academic Editor: Anna Capasso
Clin. Pract. 2022, 12(4), 482-490; https://doi.org/10.3390/clinpract12040052
Received: 22 March 2022 / Revised: 26 May 2022 / Accepted: 29 May 2022 / Published: 30 June 2022
The objective of this study was to analyze the effect of hydroxychloroquine or chloroquine associated with azithromycin on the QTc interval in Gabonese patients treated for COVID-19. Methods: This was an observational study conducted from April to June 2020, at the Libreville University Hospital Center in Gabon. Patients admitted for COVID-19 and treated with hydroxychloroquine or chloroquine, each combined with azithromycin were included. The QTc interval was measured upon admission and 48 h after starting treatment. The primary endpoint was QTc prolongation exceeding 60 ms and/or a QTc value exceeding 500 ms at 48 h. Results: Data from 224 patients, 102 (45.5%) who received hydroxychloroquine and 122 treated with chloroquine, were analyzed. The median baseline QTc was 396 (369–419) ms. After 48 h of treatment, 50 (22.3%) patients had a significant prolongation of QTc. This tended to be more frequent in patients treated with chloroquine (n = 33; 27.0%) than in those treated with hydroxychloroquine (n = 17; 16.7%) (p = 0.06). QTc prolongation exceeding 60 ms was found in 48 (21.3%) patients, while 11 patients had a (4.9%) QTc exceeding 60 ms at admission and exceeding 500 ms after 48 h. Conclusion: Early QTc prolongation is frequent in COVID-19 patients treated with hydroxychloroquine or chloroquine in association with azithromycin. View Full-Text
Keywords: hydroxychloroquine; chloroquine; COVID-19; QTc; Gabon hydroxychloroquine; chloroquine; COVID-19; QTc; Gabon
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MDPI and ACS Style

Ayo Bivigou, E.; Manomba Boulingui, C.; Bouraima, A.; Allognon, C.; Akagha Konde, C.; Atsame, G.; Kinga, A.; Boguikouma, J.B.; Kouna Ndouongo, P.; Bouyou Akotet, M.K. Early Alterations of QTc in Patients with COVID-19 Treated with Hydroxychloroquine or Chloroquine in Libreville, Gabon. Clin. Pract. 2022, 12, 482-490. https://doi.org/10.3390/clinpract12040052

AMA Style

Ayo Bivigou E, Manomba Boulingui C, Bouraima A, Allognon C, Akagha Konde C, Atsame G, Kinga A, Boguikouma JB, Kouna Ndouongo P, Bouyou Akotet MK. Early Alterations of QTc in Patients with COVID-19 Treated with Hydroxychloroquine or Chloroquine in Libreville, Gabon. Clinics and Practice. 2022; 12(4):482-490. https://doi.org/10.3390/clinpract12040052

Chicago/Turabian Style

Ayo Bivigou, Elsa, Charlene Manomba Boulingui, Aridath Bouraima, Christian Allognon, Christelle Akagha Konde, Gabrielle Atsame, Armel Kinga, Jean B. Boguikouma, Philomène Kouna Ndouongo, and Marielle K. Bouyou Akotet. 2022. "Early Alterations of QTc in Patients with COVID-19 Treated with Hydroxychloroquine or Chloroquine in Libreville, Gabon" Clinics and Practice 12, no. 4: 482-490. https://doi.org/10.3390/clinpract12040052

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