Invasive Thymoma with Pure Red Cell Aplasia and Amegakaryocytic Thrombocytopenia

Onuki, Takuya; Kiyoki, Yusuke; Ueda, Sho; Yamaoka, Masatoshi; Shimizu, Seiich; Inagaki, Masaharu

doi:10.4081/hr.2016.6680

Open AccessCase Report

Invasive Thymoma with Pure Red Cell Aplasia and Amegakaryocytic Thrombocytopenia

by

Takuya Onuki

^1,*,

Yusuke Kiyoki

²,

Sho Ueda

¹,

Masatoshi Yamaoka

¹,

Seiich Shimizu

² and

Masaharu Inagaki

¹

Department of General Thoracic Surgery, Tsuchiura Kyodo General Hospital, 4-1 Ohtsuno, Tsuchiura City, Ibaraki 300-0028, Japan

²

Department of Hematology, Tsuchiura Kyodo General Hospital, 4-1 Ohtsuno, Tsuchiura City, Ibaraki 300-0028, Japan

^*

Author to whom correspondence should be addressed.

Hematol. Rep. 2016, 8(4), 61-63; https://doi.org/10.4081/hr.2016.6680

Submission received: 30 July 2016 / Revised: 13 October 2016 / Accepted: 10 November 2016 / Published: 9 December 2016

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Abstract

We here describe a case involving a 67-yearold female patient who was referred to our hospital due to severe anemia (hemoglobin, 5.0 g/dL), thrombocytopenia (platelet count, 0.6 × 104/μL), and a mediastinal shadow with calcification noted on X-ray. On admission, an anterior mediastinal tumor was detected, and bone marrow biopsy revealed few megakaryocytes and severely reduced numbers of erythroid cells. The diagnosis was thymoma with pure red cell aplasia (PRCA) and acquired amegakaryocytic thrombocytopenia (AAMT). On Day 8 of admission, the patient received immunosuppressive therapy together with cyclosporine for the 2 severe hematologic diseases, which were stabilized within 2 months. Subsequently, total thymectomy was performed. The diagnosis of the tumor invading the left lung was invasive thymoma, Masaoka- Koga stage III. The histological diagnosis was World Health Organization type AB. Thymoma accompanied with PRCA and AAMT is very rare, and, based on our case, immunotherapeutic therapy for the hematologic disorders should precede surgical intervention.

Keywords: amegakaryocytic thrombocytopenia; Cyclosporine; pure red cell aplasia; thymoma

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MDPI and ACS Style

Onuki, T.; Kiyoki, Y.; Ueda, S.; Yamaoka, M.; Shimizu, S.; Inagaki, M. Invasive Thymoma with Pure Red Cell Aplasia and Amegakaryocytic Thrombocytopenia. Hematol. Rep. 2016, 8, 61-63. https://doi.org/10.4081/hr.2016.6680

AMA Style

Onuki T, Kiyoki Y, Ueda S, Yamaoka M, Shimizu S, Inagaki M. Invasive Thymoma with Pure Red Cell Aplasia and Amegakaryocytic Thrombocytopenia. Hematology Reports. 2016; 8(4):61-63. https://doi.org/10.4081/hr.2016.6680

Chicago/Turabian Style

Onuki, Takuya, Yusuke Kiyoki, Sho Ueda, Masatoshi Yamaoka, Seiich Shimizu, and Masaharu Inagaki. 2016. "Invasive Thymoma with Pure Red Cell Aplasia and Amegakaryocytic Thrombocytopenia" Hematology Reports 8, no. 4: 61-63. https://doi.org/10.4081/hr.2016.6680

APA Style

Onuki, T., Kiyoki, Y., Ueda, S., Yamaoka, M., Shimizu, S., & Inagaki, M. (2016). Invasive Thymoma with Pure Red Cell Aplasia and Amegakaryocytic Thrombocytopenia. Hematology Reports, 8(4), 61-63. https://doi.org/10.4081/hr.2016.6680

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Invasive Thymoma with Pure Red Cell Aplasia and Amegakaryocytic Thrombocytopenia

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