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Hematology Reports
Volume 8
Issue 4
10.4081/hr.2016.6592
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Case Report

Treatment of Refractory Anemia with Ring Sideroblasts Associated with Marked Thrombocytosis with Lenalidomide in a Patient testing Negative for 5q Deletion and JAK2 V617F and MPL W515K/L Mutations

by
Ryan Keen
1,
Jeremy Pantin
2,
Natasha Savage
3 and
Paul M. Dainer
2,*
1
Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912-3125, USA
2
Section of Hematology/Oncology, Medical College of Georgia, BAA-5407, 1120 15th Street, Augusta, GA 30912-3125, USA
3
Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA 30912-3125, USA
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2016, 8(4), 48-50; https://doi.org/10.4081/hr.2016.6592
Submission received: 10 May 2016 / Revised: 6 July 2016 / Accepted: 11 October 2016 / Published: 2 November 2016

Abstract

Refractory anemia with ring sideroblasts associated with marked thrombocytosis (RARS-T) is a hematologic malignancy that often results in transfusion dependency and a hypercoagulable state. This rare disease currently lacks formal guidelines for treatment; however, various case reports have demonstrated efficacy in the use of lenalidomide. This immunomodulatory drug has shown promise in patients with 5q deletions, with reports of achieving transfusion independence and normalization of platelet counts. Herein we present the case of a 68-year-old African American woman with RARS-T who tested negative for 5q deletion and JAK2 V617F and MPL W515K/L mutations. Her treatment with lenalidomide therapy resulted in a five-year durable complete clinical response.
Keywords: myelodysplastic-myeloproliferative diseases; anemia; refractory; platelet count; lenalidomide myelodysplastic-myeloproliferative diseases; anemia; refractory; platelet count; lenalidomide

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MDPI and ACS Style

Keen, R.; Pantin, J.; Savage, N.; Dainer, P.M. Treatment of Refractory Anemia with Ring Sideroblasts Associated with Marked Thrombocytosis with Lenalidomide in a Patient testing Negative for 5q Deletion and JAK2 V617F and MPL W515K/L Mutations. Hematol. Rep. 2016, 8, 48-50. https://doi.org/10.4081/hr.2016.6592

AMA Style

Keen R, Pantin J, Savage N, Dainer PM. Treatment of Refractory Anemia with Ring Sideroblasts Associated with Marked Thrombocytosis with Lenalidomide in a Patient testing Negative for 5q Deletion and JAK2 V617F and MPL W515K/L Mutations. Hematology Reports. 2016; 8(4):48-50. https://doi.org/10.4081/hr.2016.6592

Chicago/Turabian Style

Keen, Ryan, Jeremy Pantin, Natasha Savage, and Paul M. Dainer. 2016. "Treatment of Refractory Anemia with Ring Sideroblasts Associated with Marked Thrombocytosis with Lenalidomide in a Patient testing Negative for 5q Deletion and JAK2 V617F and MPL W515K/L Mutations" Hematology Reports 8, no. 4: 48-50. https://doi.org/10.4081/hr.2016.6592

APA Style

Keen, R., Pantin, J., Savage, N., & Dainer, P. M. (2016). Treatment of Refractory Anemia with Ring Sideroblasts Associated with Marked Thrombocytosis with Lenalidomide in a Patient testing Negative for 5q Deletion and JAK2 V617F and MPL W515K/L Mutations. Hematology Reports, 8(4), 48-50. https://doi.org/10.4081/hr.2016.6592

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