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Hematology Reports
Volume 7
Issue 3
10.4081/hr.2015.5897
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Case Report

A Rare Case of Myelodysplastic Syndrome with Refractory Thrombocytopenia

by
Waqas Jehangir
1,*,
John Webb
2,
Shilpi Singh
1,
Sabrina Arshed
1,
Shuvendu Sen
1 and
Abdalla Yousif
1
1
Raritan Bay Medical Center, 530 New Brunswick Avenue, Perth Amboy, NJ 08861, USA
2
Ross University School of Medicine, Portsmouth, Dominica
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2015, 7(3), 5897; https://doi.org/10.4081/hr.2015.5897
Submission received: 23 April 2015 / Revised: 7 August 2015 / Accepted: 2 September 2015 / Published: 23 September 2015

Abstract

Myelodysplastic syndromes (MDS) represent a variety of clonal abnormalities, possibly preleukemic and display numerous phenotypic manifestations. Specific mutations carry high morbidity and mortality rates due to cell line dysplasia. MDS commonly presents with symptoms related to anemia, and approximately two-thirds will develop thrombocytopenia, a rare, but potentially lethal complication that increases complexity in treatment and morbidity, and may be due to unique genetic mutations leading to refractory thrombocytopenia, ultimately leading to an overall reduction in survival. Careful identification and monitoring of this patient subdivision can significantly reduce morbidity and mortality, and potential identification of specific gene mutations and advances in treatment options will hopefully provide guidance on detecting at-risk patients in the future. We present a case of a man with MDS-U (karyotype 46, XY, del (20) (q11.2q13.3) (20) with no detected JAK2 V617F mutation), who in despite of appropriate evidenced based treatment, continued to exhibit refractory thrombocytopenia.
Keywords: thrombocytopenia; myelodysplasia; refractory; MDS; malignancy thrombocytopenia; myelodysplasia; refractory; MDS; malignancy

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MDPI and ACS Style

Jehangir, W.; Webb, J.; Singh, S.; Arshed, S.; Sen, S.; Yousif, A. A Rare Case of Myelodysplastic Syndrome with Refractory Thrombocytopenia. Hematol. Rep. 2015, 7, 5897. https://doi.org/10.4081/hr.2015.5897

AMA Style

Jehangir W, Webb J, Singh S, Arshed S, Sen S, Yousif A. A Rare Case of Myelodysplastic Syndrome with Refractory Thrombocytopenia. Hematology Reports. 2015; 7(3):5897. https://doi.org/10.4081/hr.2015.5897

Chicago/Turabian Style

Jehangir, Waqas, John Webb, Shilpi Singh, Sabrina Arshed, Shuvendu Sen, and Abdalla Yousif. 2015. "A Rare Case of Myelodysplastic Syndrome with Refractory Thrombocytopenia" Hematology Reports 7, no. 3: 5897. https://doi.org/10.4081/hr.2015.5897

APA Style

Jehangir, W., Webb, J., Singh, S., Arshed, S., Sen, S., & Yousif, A. (2015). A Rare Case of Myelodysplastic Syndrome with Refractory Thrombocytopenia. Hematology Reports, 7(3), 5897. https://doi.org/10.4081/hr.2015.5897

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