Next Article in Journal
Pneumothorax in an Early Phase after Allogeneic Hematopoietic Stem Cell Transplantation
Previous Article in Journal
10th International Hereditary Hemorrhagic Telangiectasia Scientific Conference, 12-15 June 2013 - Cork, Ireland
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Hematology Reports
Volume 5
Issue 2
10.4081/hr.2013.e11
hematolrep-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Case Report

An Attempt to Induce Transient Immunosuppression Pre-Erythrocytapheresis in a Girl with Sickle Cell Disease, a History of Severe Delayed Hemolytic Transfusion Reactions and Need for Hip Prosthesis

by
Alessandro Cattoni
1,
Giovanni Cazzaniga
2,
Paolo Perseghin
3,
Giovanni Zatti
4,
Diego Gaddi
4,
Andrea Cossio
4,
Andrea Biondi
1,
Paola Corti
1 and
Nicoletta Masera
1,*
1
Pediatric Department, University of Milano-Bicocca, San Gerardo Hospital, Via Pergolesi 33, 20052 Monza, MB, Italy
2
Immunotransfusional Service, University of Milano-Bicocca, San Gerardo Hospital, Via Pergolesi 33, 20052 Monza, MB, Italy
3
Apheresis Unit, University of Milano-Bicocca, San Gerardo Hospital, Via Pergolesi 33, 20052 Monza, MB, Italy
4
Orthopedic Department, University of Milano-Bicocca, San Gerardo Hospital, Via Pergolesi 33, 20052 Monza, MB, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2013, 5(2), e11; https://doi.org/10.4081/hr.2013.e11
Submission received: 12 March 2013 / Revised: 19 May 2013 / Accepted: 21 June 2013 / Published: 28 June 2013

Abstract

We report on a case of delayed hemolytic transfusion reaction (DHTR) occurred 7 days after an erythrocytapheresis or eritroexchange procedure (EEX) treated with rituximab and glucocorticoids in a 15-years old patient with sickle cell disease. EEX was performed despite a previous diagnosis of alloimmunization, in order to reduce hemoglobin S rate before a major surgery for avascular necrosis of the femoral head. A first dose of rituximab was administered before EEX. However, rituximab couldn’t prevent DHTR that occurred with acute hemolysis, hemoglobinuria and hyper-bilirubinemia. A further dose of rituximab and three boli of methylprednisolone were given after the onset of the reaction. It is likely that the combined use of rituximab and steroids managed to gradually improve both patient’s general conditions and hemoglobin levels. Nor early or late side effects were registered in a 33-months follow-up period. This report suggests the potential effectiveness and safety of rituximab in combination with steroids in managing and mitigating the symptoms of delayed post-transfusional hemolytic reactions in alloimmunized patients affected by sickle cell disease with absolute need for erythrocytapheresis.
Keywords: erythrocytapheresis; rituximab; alloimunization; avascular necrosis of femoral head; sickle cell disesase erythrocytapheresis; rituximab; alloimunization; avascular necrosis of femoral head; sickle cell disesase

Share and Cite

MDPI and ACS Style

Cattoni, A.; Cazzaniga, G.; Perseghin, P.; Zatti, G.; Gaddi, D.; Cossio, A.; Biondi, A.; Corti, P.; Masera, N. An Attempt to Induce Transient Immunosuppression Pre-Erythrocytapheresis in a Girl with Sickle Cell Disease, a History of Severe Delayed Hemolytic Transfusion Reactions and Need for Hip Prosthesis. Hematol. Rep. 2013, 5, e11. https://doi.org/10.4081/hr.2013.e11

AMA Style

Cattoni A, Cazzaniga G, Perseghin P, Zatti G, Gaddi D, Cossio A, Biondi A, Corti P, Masera N. An Attempt to Induce Transient Immunosuppression Pre-Erythrocytapheresis in a Girl with Sickle Cell Disease, a History of Severe Delayed Hemolytic Transfusion Reactions and Need for Hip Prosthesis. Hematology Reports. 2013; 5(2):e11. https://doi.org/10.4081/hr.2013.e11

Chicago/Turabian Style

Cattoni, Alessandro, Giovanni Cazzaniga, Paolo Perseghin, Giovanni Zatti, Diego Gaddi, Andrea Cossio, Andrea Biondi, Paola Corti, and Nicoletta Masera. 2013. "An Attempt to Induce Transient Immunosuppression Pre-Erythrocytapheresis in a Girl with Sickle Cell Disease, a History of Severe Delayed Hemolytic Transfusion Reactions and Need for Hip Prosthesis" Hematology Reports 5, no. 2: e11. https://doi.org/10.4081/hr.2013.e11

APA Style

Cattoni, A., Cazzaniga, G., Perseghin, P., Zatti, G., Gaddi, D., Cossio, A., Biondi, A., Corti, P., & Masera, N. (2013). An Attempt to Induce Transient Immunosuppression Pre-Erythrocytapheresis in a Girl with Sickle Cell Disease, a History of Severe Delayed Hemolytic Transfusion Reactions and Need for Hip Prosthesis. Hematology Reports, 5(2), e11. https://doi.org/10.4081/hr.2013.e11

Article Metrics

Back to TopTop