Next Article in Journal
A Case of Acute Promyelocytic Leukemia with Morphologic Multilineage Dysplastic Changes
Previous Article in Journal
Extent of Silent Cerebral Infarcts in Adult Sickle-Cell Disease Patients on Magnetic Resonance Imaging: Is There a Correlation with the Clinical Severity of Disease?
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Hematology Reports
Volume 5
Issue 1
10.4081/hr.2013.e4
hematolrep-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Male-to-Female Sex Ratios of Abnormalities Detected by Fluorescence In Situ Hybridization in a Population of Chronic Lymphocytic Leukemia Patients

by
Eduardo S. Cantú
1,*,
John R. McGill
2,
Christine F. Stephenson
3,
Heidi M. Hoffmann
4,
Lihua Tang
5,
Jim Yan
5 and
Armand B. Glassman
6
1
Integrated Oncology, LabCorp Specialty Testing Group Cytogenetics & FISH Laboratories, 4310 E. Cotton Center Boulevard, Suite 120, Phoenix, AZ 85040, USA
2
Miraca Life Sciences, Phoenix, AZ 85040, USA
3
Hematologics, Inc., Seattle, WA 98121, USA
4
Integrated Genetics, Information Technology, Westborough, MA 01581, USA
5
Research and Bioinformatics, Laboratory Corporation of America Holdings, Durham, NC 27703, USA
6
Department of Microbiology & Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2013, 5(1), e4; https://doi.org/10.4081/hr.2013.e4
Submission received: 27 October 2012 / Revised: 16 January 2013 / Accepted: 24 January 2013 / Published: 11 February 2013

Abstract

Distorted sex ratios occur in hematologic disorders. For example, chronic lymphocytic leukemia (CLL) displays disproportionate sex ratios with a large male excess. However, the underlying genetics for these disparities are poorly understood, and gender differences for specific cytogenetic abnormalities have not been carefully investigated. We sought to provide an initial characterization of gender representation in genetic abnormalities in CLL by using fluorescence in situ hybridization (FISH). We confirm the well known skewed male-to-female (M/F sex ratio) of ~1.5 in our CLL study population, but also determine the genotypic M/F sex ratio values corresponding to specific FISH DNA probes. Genetic changes in CLL detectable by four FISH probes were statistically compared with respect to gender. Initial FISH evaluations of 4698 CLL patients were retrospectively examined and new findings of the genotypic M/F sex ratios for these probes are reported. This study represents the largest CLL survey conducted in the United States using FISH probes. The CLL database demonstrated that FISH abnormalities (trisomy 12, 13q14.3 deletion and 17p13.1 deletion) probes had skewed M/F ratios of ~1.5. Also, by statistical analysis it was shown that ATM gene loss (11q22.3q23.1 deletion) solely or with other abnormalities was considerably higher in males with an M/F ratio of 2.5 and significantly different from M/F ratios of 1.0 or 1.5. We hypothesize that interactions involving these autosomal abnormalities (trisomy 12, and deletions of 11q22.3, 13q14.3, and 17p13.1), and the sex chromosomes may provide the genetic basis for the altered phenotypic M/F ratio in CLL.
Keywords: sex ratios; CLL; FISH sex ratios; CLL; FISH

Share and Cite

MDPI and ACS Style

Cantú, E.S.; McGill, J.R.; Stephenson, C.F.; Hoffmann, H.M.; Tang, L.; Yan, J.; Glassman, A.B. Male-to-Female Sex Ratios of Abnormalities Detected by Fluorescence In Situ Hybridization in a Population of Chronic Lymphocytic Leukemia Patients. Hematol. Rep. 2013, 5, e4. https://doi.org/10.4081/hr.2013.e4

AMA Style

Cantú ES, McGill JR, Stephenson CF, Hoffmann HM, Tang L, Yan J, Glassman AB. Male-to-Female Sex Ratios of Abnormalities Detected by Fluorescence In Situ Hybridization in a Population of Chronic Lymphocytic Leukemia Patients. Hematology Reports. 2013; 5(1):e4. https://doi.org/10.4081/hr.2013.e4

Chicago/Turabian Style

Cantú, Eduardo S., John R. McGill, Christine F. Stephenson, Heidi M. Hoffmann, Lihua Tang, Jim Yan, and Armand B. Glassman. 2013. "Male-to-Female Sex Ratios of Abnormalities Detected by Fluorescence In Situ Hybridization in a Population of Chronic Lymphocytic Leukemia Patients" Hematology Reports 5, no. 1: e4. https://doi.org/10.4081/hr.2013.e4

APA Style

Cantú, E. S., McGill, J. R., Stephenson, C. F., Hoffmann, H. M., Tang, L., Yan, J., & Glassman, A. B. (2013). Male-to-Female Sex Ratios of Abnormalities Detected by Fluorescence In Situ Hybridization in a Population of Chronic Lymphocytic Leukemia Patients. Hematology Reports, 5(1), e4. https://doi.org/10.4081/hr.2013.e4

Article Metrics

Back to TopTop