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Hematology Reports
Volume 5
Issue 1
10.4081/hr.2013.e2
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Article

Thrombotic Thrombocytopenic Purpura in a Patient with Interferon Treated Hepatitis C Successfully Treated with Rituximab

by
Nishant Poddar
and
Jen C. Wang
*
Division of Hematology/Oncology, Brookdale University Hospital Medical Center, Brooklyn, NY 11212, USA
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2013, 5(1), e2; https://doi.org/10.4081/hr.2013.e2
Submission received: 25 July 2012 / Revised: 18 December 2012 / Accepted: 7 January 2013 / Published: 25 January 2013

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a life threatening condition associated with formation of platelet thrombi. Deficiency of ADAM TS 13 with presence of inhibitory anti-ADAM TS 13 Immunoglobulin G antibody is seen in patients with acquired TTP. TTP in patients on interferon therapy for chronic hepatitis C has rarely been reported. Furthermore, successful treatment of an initial episode of acute refractory acquired TTP, in a patient of chronic hepatitis C during interferon therapy with Rituximab, has not been previously reported. Here we describe a case of acute refractory acquired TTP associated with pegylated interferon therapy for her chronic hepatitis C infection. Initially refractory to plasmapheresis and steroids, she was successfully treated with Rituximab and plasmaphersis without any evidence of reactivation of hepatitis.
Keywords: thrombotic thrombocytopenic purpura; interferon; hepatitis C; Rituximab thrombotic thrombocytopenic purpura; interferon; hepatitis C; Rituximab

Share and Cite

MDPI and ACS Style

Poddar, N.; Wang, J.C. Thrombotic Thrombocytopenic Purpura in a Patient with Interferon Treated Hepatitis C Successfully Treated with Rituximab. Hematol. Rep. 2013, 5, e2. https://doi.org/10.4081/hr.2013.e2

AMA Style

Poddar N, Wang JC. Thrombotic Thrombocytopenic Purpura in a Patient with Interferon Treated Hepatitis C Successfully Treated with Rituximab. Hematology Reports. 2013; 5(1):e2. https://doi.org/10.4081/hr.2013.e2

Chicago/Turabian Style

Poddar, Nishant, and Jen C. Wang. 2013. "Thrombotic Thrombocytopenic Purpura in a Patient with Interferon Treated Hepatitis C Successfully Treated with Rituximab" Hematology Reports 5, no. 1: e2. https://doi.org/10.4081/hr.2013.e2

APA Style

Poddar, N., & Wang, J. C. (2013). Thrombotic Thrombocytopenic Purpura in a Patient with Interferon Treated Hepatitis C Successfully Treated with Rituximab. Hematology Reports, 5(1), e2. https://doi.org/10.4081/hr.2013.e2

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