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Hematology Reports
Volume 10
Issue 3
10.4081/hr.2018.7605
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

The Role of Red Cell Distribution Width in the Differential Diagnosis of Iron Deficiency Anemia and Non-Transfusion-Dependent Thalassemia Patients

by
Pokpong Piriyakhuntorn
,
Adisak Tantiworawit
*,
Thanawat Rattanathammethee
,
Chatree Chai-Adisaksopha
,
Ekarat Rattarittamrong
and
Lalita Norasetthada
Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Intravaroros Road, A. Muang, Chiang Mai 50200, Thailand
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2018, 10(3), 7605; https://doi.org/10.4081/hr.2018.7605
Submission received: 23 January 2018 / Revised: 3 June 2018 / Accepted: 29 June 2018 / Published: 5 September 2018

Abstract

This study aims to find the cut-off value and diagnostic accuracy of the use of RDW as initial investigation in enabling the differentiation between IDA and NTDT patients. Patients with microcytic anemia were enrolled in the training set and used to plot a receiving operating characteristics (ROC) curve to obtain the cut-off value of RDW. A second set of patients were included in the validation set and used to analyze the diagnostic accuracy. We recruited 94 IDA and 64 NTDT patients into the training set. The area under the curve of the ROC in the training set was 0.803. The best cut-off value of RDW in the diagnosis of NTDT was >21.0% with a sensitivity and specificity of 81.3% and 55.3% respectively. In the validation set, there were 34 IDA and 58 NTDT patients using the cut-off value of >21.0% to validate. The sensitivity, specificity, positive predictive value and negative predictive value were 84.5%, 70.6%, 83.1% and 72.7% respectively. We can therefore conclude that RDW >21.0% is useful in differentiating between IDA and NTDT patients with high diagnostic accuracy.
Keywords: red cell distribution width; microcytic anemia; iron deficiency anemia; non-transfusion-dependent thalassemia red cell distribution width; microcytic anemia; iron deficiency anemia; non-transfusion-dependent thalassemia

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MDPI and ACS Style

Piriyakhuntorn, P.; Tantiworawit, A.; Rattanathammethee, T.; Chai-Adisaksopha, C.; Rattarittamrong, E.; Norasetthada, L. The Role of Red Cell Distribution Width in the Differential Diagnosis of Iron Deficiency Anemia and Non-Transfusion-Dependent Thalassemia Patients. Hematol. Rep. 2018, 10, 7605. https://doi.org/10.4081/hr.2018.7605

AMA Style

Piriyakhuntorn P, Tantiworawit A, Rattanathammethee T, Chai-Adisaksopha C, Rattarittamrong E, Norasetthada L. The Role of Red Cell Distribution Width in the Differential Diagnosis of Iron Deficiency Anemia and Non-Transfusion-Dependent Thalassemia Patients. Hematology Reports. 2018; 10(3):7605. https://doi.org/10.4081/hr.2018.7605

Chicago/Turabian Style

Piriyakhuntorn, Pokpong, Adisak Tantiworawit, Thanawat Rattanathammethee, Chatree Chai-Adisaksopha, Ekarat Rattarittamrong, and Lalita Norasetthada. 2018. "The Role of Red Cell Distribution Width in the Differential Diagnosis of Iron Deficiency Anemia and Non-Transfusion-Dependent Thalassemia Patients" Hematology Reports 10, no. 3: 7605. https://doi.org/10.4081/hr.2018.7605

APA Style

Piriyakhuntorn, P., Tantiworawit, A., Rattanathammethee, T., Chai-Adisaksopha, C., Rattarittamrong, E., & Norasetthada, L. (2018). The Role of Red Cell Distribution Width in the Differential Diagnosis of Iron Deficiency Anemia and Non-Transfusion-Dependent Thalassemia Patients. Hematology Reports, 10(3), 7605. https://doi.org/10.4081/hr.2018.7605

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