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Pediatric Reports
Volume 8
Issue 2
10.4081/pr.2016.6488
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Article

Non Activated Protein C Supplementation in Septic Pediatric Hematological Patients

by
Teresa Perillo
*,
Paola Muggeo
,
Giampaolo Arcamone
,
Francesco De Leonardis
and
Nicola Santoro
Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Bari, Italy
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2016, 8(2), 6488; https://doi.org/10.4081/pr.2016.6488
Submission received: 28 February 2016 / Revised: 17 April 2016 / Accepted: 23 May 2016 / Published: 15 June 2016

Abstract

The purpose of the study was to examine safety and efficacy of non-activated Protein C (PC) supplementation in our cohort of septic pediatric hematological patients. We conducted a retrospective study of 22 septic patients receiving human plasma-derived PC concentrate from 2008 to 2015 at our Pediatric Oncology Center (Bari, Italy). The Surviving sepsis campaign definitions for sepsis, severe sepsis and septic shock were used to define the patients’ septic status. For each patient, we calculated Lansky performance status scale (LPSS) and a risk score defined the Hematologic risk score (HRS) that we created in 2007. Patients were defined as High risk for severe sepsis/septic shock in case of HRS>3. HRS10% PC concentration decrease within 12 hours from the first evaluation. All patients received 80 U/kg/day PC, intravenously, every twenty-four hours. No drug-related adverse event was observed. The observed sepsis-related mortality rate in our cohort was 9%. PC supplementation in our cohort appeared to be safe, and, probably due to prompt PC administration, we observed an overall mortality that was much lower than expected mortality in cancer severe septic patients.
Keywords: Protein C; sepsis; pediatrics; supplementation; leukemia Protein C; sepsis; pediatrics; supplementation; leukemia

Share and Cite

MDPI and ACS Style

Perillo, T.; Muggeo, P.; Arcamone, G.; De Leonardis, F.; Santoro, N. Non Activated Protein C Supplementation in Septic Pediatric Hematological Patients. Pediatr. Rep. 2016, 8, 6488. https://doi.org/10.4081/pr.2016.6488

AMA Style

Perillo T, Muggeo P, Arcamone G, De Leonardis F, Santoro N. Non Activated Protein C Supplementation in Septic Pediatric Hematological Patients. Pediatric Reports. 2016; 8(2):6488. https://doi.org/10.4081/pr.2016.6488

Chicago/Turabian Style

Perillo, Teresa, Paola Muggeo, Giampaolo Arcamone, Francesco De Leonardis, and Nicola Santoro. 2016. "Non Activated Protein C Supplementation in Septic Pediatric Hematological Patients" Pediatric Reports 8, no. 2: 6488. https://doi.org/10.4081/pr.2016.6488

APA Style

Perillo, T., Muggeo, P., Arcamone, G., De Leonardis, F., & Santoro, N. (2016). Non Activated Protein C Supplementation in Septic Pediatric Hematological Patients. Pediatric Reports, 8(2), 6488. https://doi.org/10.4081/pr.2016.6488

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