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Volume 5
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10.4081/pr.2013.e17
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Article

Diagnosis of Biliary Atresia Can Not Be Excluded by Declining Trend of Serum Direct Bilirubin

by
Keita Terui
1,*,
Yasuyuki Higashimoto
2,
Eriko Saito
3,
Takeshi Saito
1,
Tetsuya Mitsuanga
1,
Mitsuyuki Nakata
1,
Jun Iwai
2 and
Hideo Yoshida
1
1
Department of Pediatric Surgery, Graduate School of Medicine, Chiba University
2
Department of Pediatric Surgery, Chiba Children’s Hospital
3
Department of Pediatric Surgery, Matsudo City Hospital Children’s Medical Center, Japan
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2013, 5(4), e17; https://doi.org/10.4081/pr.2013.e17
Submission received: 23 July 2013 / Revised: 23 July 2013 / Accepted: 7 November 2013 / Published: 18 November 2013

Abstract

The aim of this paper is to investigate the clinical courses of patients with biliary atresia (BA) during neonatal period. We examined 19 patients with BA, who underwent blood tests including direct bilirubin (D-Bil) within 20 days of age, in 3 tertiary hospitals in Japan. The first blood sample was collected at 8.4±6.5 days of age. The acholic stool was observed within 2 weeks of age in 16 cases (84.2%). Decrease of T-Bil was observed in all the subjects, with a range of reduction of 6.5±3.3 mg/dL, from 10.4±7.5 to 29.8±9.1 days of age. Decrease of D-Bil was also observed in 17 out of 19 cases (89%), with a range of reduction of 1.1±1.0 mg/dL, from 15.5±8.0 to 24.9±9.6 days of age. A significant decrease of D-Bil was observed in 2 cases of biliary atresia splenic malformation syndrome. We therefore conclude that clinicians treating icteric infants should not exclude a diagnosis of BA even if the level of D-Bil has a declining tendency.
Keywords: biliary atresia; bilirubin; hyperbilirubinemia; neonate; jaundice biliary atresia; bilirubin; hyperbilirubinemia; neonate; jaundice

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MDPI and ACS Style

Terui, K.; Higashimoto, Y.; Saito, E.; Saito, T.; Mitsuanga, T.; Nakata, M.; Iwai, J.; Yoshida, H. Diagnosis of Biliary Atresia Can Not Be Excluded by Declining Trend of Serum Direct Bilirubin. Pediatr. Rep. 2013, 5, e17. https://doi.org/10.4081/pr.2013.e17

AMA Style

Terui K, Higashimoto Y, Saito E, Saito T, Mitsuanga T, Nakata M, Iwai J, Yoshida H. Diagnosis of Biliary Atresia Can Not Be Excluded by Declining Trend of Serum Direct Bilirubin. Pediatric Reports. 2013; 5(4):e17. https://doi.org/10.4081/pr.2013.e17

Chicago/Turabian Style

Terui, Keita, Yasuyuki Higashimoto, Eriko Saito, Takeshi Saito, Tetsuya Mitsuanga, Mitsuyuki Nakata, Jun Iwai, and Hideo Yoshida. 2013. "Diagnosis of Biliary Atresia Can Not Be Excluded by Declining Trend of Serum Direct Bilirubin" Pediatric Reports 5, no. 4: e17. https://doi.org/10.4081/pr.2013.e17

APA Style

Terui, K., Higashimoto, Y., Saito, E., Saito, T., Mitsuanga, T., Nakata, M., Iwai, J., & Yoshida, H. (2013). Diagnosis of Biliary Atresia Can Not Be Excluded by Declining Trend of Serum Direct Bilirubin. Pediatric Reports, 5(4), e17. https://doi.org/10.4081/pr.2013.e17

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