Next Article in Journal
Does Intravenous Immunoglobulin Therapy Prolong Immunodeficiency in Transient Hypogammaglobulinemia of Infancy?
Previous Article in Journal
Maternal Coping Strategies in Response to a Child’s Chronic and Oncological Disease: A Cross-Cultural Study in Italy and Portugal
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pediatric Reports
Volume 5
Issue 3
10.4081/pr.2013.e13
pediatrrep-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Pediatric Reports is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Case Report

Central Precocious Puberty and Granulosa Cell Ovarian Tumor in an 8-Year Old Female

by
Valeria Calcaterra
1,
Ghassan Nakib
2,
Gloria Pelizzo
2,
Barbara Rundo
1,
Gaetana Anna Rispoli
3,
Stella Boghen
1,
Federico Bonetti
4,
Barbara Del Monte
5,
Chiara Gertosio
1 and
Daniela Larizza
1,*
1
Department of the Mother and Child Health, Pediatric Unit, IRCCS Policlinico San Matteo Foundation and Department of Internal Medicine, University of Pavia
2
Department of the Mother and Child Health, Pediatric Surgery Unit, IRCCS Policlinico San Matteo Foundation and University of Pavia
3
Department of Neuroradiology, IRCCS Policlinico San Matteo Foundation Pavia
4
Department of the Mother and Child Health, Haematologic/Oncologic Unit, IRCCS Policlinico San Matteo Foundation, Pavia
5
Anatomic Pathology Section, Department of Human Pathology, University of Pavia, Foundation IRCCS Policlinico San Matteo, Pavia, Italy
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2013, 5(3), e13; https://doi.org/10.4081/pr.2013.e13
Submission received: 9 June 2013 / Revised: 9 June 2013 / Accepted: 8 July 2013 / Published: 29 July 2013

Abstract

Ovarian tumors associated with hormonal changes of the peripheral iso-sexual precocious puberty are of common presentation. We describe here a rare case of juvenile granulosa cell tumor in a female with central precocious puberty (CPP). An 8-year old girl with CPP presented with vaginal bleeding four months after the diagnosis and before starting treatment with gonadotropin-releasing hormone (GnRH)-analogs. Suppression of basal follicle-stimulating hormone (FSH) level, elevation of serum estradiol, progesterone and Cancer Antigen-125 were documented. Abdominal ultrasound examination (US) and magnetic resonance imaging showed a pelvic mass affecting the left ovary. A left salpingo-oophorectomy was performed and the mass was totally resected. Juvenile granulosa cell ovarian tumor was diagnosed. One month post surgery, estradiol and progesterone decreased to values of the first evaluation and FSH increased; Cancer Antigen-125 resulted normal while ultrasound pelvic examination showed absence of pelvic masses. In our patient, the tumor had grown very quickly since hormonal data demonstrated a CPP without any evidence of ovarian mass on US only four months before diagnosis. The overstimulation of the FSH or aberrant activation of FSH receptors may have contributed to the development of the mass.
Keywords: central precocious puberty; juvenile granulosa cell; ovarian tumor; children central precocious puberty; juvenile granulosa cell; ovarian tumor; children

Share and Cite

MDPI and ACS Style

Calcaterra, V.; Nakib, G.; Pelizzo, G.; Rundo, B.; Rispoli, G.A.; Boghen, S.; Bonetti, F.; Del Monte, B.; Gertosio, C.; Larizza, D. Central Precocious Puberty and Granulosa Cell Ovarian Tumor in an 8-Year Old Female. Pediatr. Rep. 2013, 5, e13. https://doi.org/10.4081/pr.2013.e13

AMA Style

Calcaterra V, Nakib G, Pelizzo G, Rundo B, Rispoli GA, Boghen S, Bonetti F, Del Monte B, Gertosio C, Larizza D. Central Precocious Puberty and Granulosa Cell Ovarian Tumor in an 8-Year Old Female. Pediatric Reports. 2013; 5(3):e13. https://doi.org/10.4081/pr.2013.e13

Chicago/Turabian Style

Calcaterra, Valeria, Ghassan Nakib, Gloria Pelizzo, Barbara Rundo, Gaetana Anna Rispoli, Stella Boghen, Federico Bonetti, Barbara Del Monte, Chiara Gertosio, and Daniela Larizza. 2013. "Central Precocious Puberty and Granulosa Cell Ovarian Tumor in an 8-Year Old Female" Pediatric Reports 5, no. 3: e13. https://doi.org/10.4081/pr.2013.e13

APA Style

Calcaterra, V., Nakib, G., Pelizzo, G., Rundo, B., Rispoli, G. A., Boghen, S., Bonetti, F., Del Monte, B., Gertosio, C., & Larizza, D. (2013). Central Precocious Puberty and Granulosa Cell Ovarian Tumor in an 8-Year Old Female. Pediatric Reports, 5(3), e13. https://doi.org/10.4081/pr.2013.e13

Article Metrics

Back to TopTop