Next Article in Journal
Neuroleptic Malignant Syndrome Due to Risperidone Misdiagnosed as Status Epilepticus
Previous Article in Journal
How Does the NPM1 Mutant Induce Leukemia?
Pediatric Reports is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on as a courtesy and upon agreement with PAGEPress.
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:

Antituberculosis Drug-Induced Hepatotoxicity in Children

Department of Paediatrics and Child Health, Faculty of Health Sciences, University of Stellenbosch and Tygerberg Children’s Hospital, Tygerberg, South Africa
Pediatr. Rep. 2011, 3(2), e16;
Submission received: 10 January 2011 / Revised: 10 January 2011 / Accepted: 31 March 2011 / Published: 20 June 2011


Recent increases in the dosages of the essential antituberculosis agents isoniazid (INH), rifampicin and pyrazinamide for use in children recommended by World Health Organization have raised concerns regarding the risk of hepatotoxicity. Published data relating to the incidence and pathogenesis of antituberculosis drug-induced hepatotoxicity (ADIH), particularly in children, is reviewed. Amongst 12,708 children receiving chemoprophylaxis, mainly with INH, but also other combinations of INH, rifampicin and pyrazinamide only 1 case (0.06%) of jaundice was recorded and abnormal liver functions documented in 110 (8%) of the 1225 children studied. Excluding tuberculous meningitis (TBM) 8984 were children treated for tuberculosis disease and jaundice documented in 75 (0.83%) and abnormal liver function tests in 380 (9.9%) of the 3855 children evaluated. Amongst 717 children treated for TBM, however, jaundice occurred in 72 (10.8%) and abnormal LFT were recorded in 174 (52.9%) of those studied. Case reports document the occurrence of ADIH in at least 63 children. Signs and symptoms of ADIH were frequently ignored in the recorded cases. Conclusion: ADIH is less common in children than adults, but can occur in children at any dosage of INH, RMP or PZA, but its incidence is considerably lower than in adults. Children with disseminated forms of disease are at greater risk of ADIH.
Keywords: antituberculosis chemotherapy; hepa-totoxicity; children; isoniazid; rifampicin; pyrazi-namide antituberculosis chemotherapy; hepa-totoxicity; children; isoniazid; rifampicin; pyrazi-namide

Share and Cite

MDPI and ACS Style

Donald, P.R. Antituberculosis Drug-Induced Hepatotoxicity in Children. Pediatr. Rep. 2011, 3, e16.

AMA Style

Donald PR. Antituberculosis Drug-Induced Hepatotoxicity in Children. Pediatric Reports. 2011; 3(2):e16.

Chicago/Turabian Style

Donald, Peter R. 2011. "Antituberculosis Drug-Induced Hepatotoxicity in Children" Pediatric Reports 3, no. 2: e16.

Article Metrics

Back to TopTop