Next Article in Journal
Protein-Losing Enteropathy Associated with Henoch-Schönlein Purpura
Previous Article in Journal
Colonic Phasic Motor Activity Is Stronger in Patients with Repaired Anorectal Malformations than Patients with Severe Colonic Dismotility
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pediatric Reports
Volume 2
Issue 2
10.4081/pr.2010.e19
pediatrrep-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Pediatric Reports is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Impact of Child Obesity on Adipose Tissue Physiology: Assessment of Adipocytokines and Inflammatory Cytokines as Biomarkers of Obesity

by
Maria Chiara Leoni
1,
Chiara Valsecchi
2,
Melissa Mantelli
2,
Laura Marastoni
2,
Carmine Tinelli
3,
Antonietta Marchi
1 and
Annamaria Castellazzi
2,*
1
Paediatric Clinic, University of Pavia, Foundation IRCCS Policlinico San Matteo, Pavia, Italy
2
Department of Pediatric Sciences, Foundation IRCCS Policlinico San Matteo, University of Pavia, Italy
3
Clinical Epidemiology and Biometrics Unit, Foundation IRCCS Policlinico San Matteo, Pavia, Italy
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2010, 2(2), e19; https://doi.org/10.4081/pr.2010.e19
Submission received: 3 February 2010 / Revised: 23 November 2010 / Accepted: 24 November 2010 / Published: 15 December 2010

Abstract

Obesity could be interpreted as a low grade inflammatory state. The role of cytokines for innate and acquired immune response and adipocytokines in pathogenesis of obesity is not completely understood. The aim of the study was to evaluate anthropometric parameters, adipocytokines and inflammatory cytokine levels as biomarkers of childhood obesity. This investigation was designed as a longitudinal observational study. Forty-seven obese children (19 males and 28 females) were enrolled by Pediatric Clinic of the Foundation IRCCS Policlinico San Matteo, Pavia, Italy. For each patients a blood sample, used for other biochemical evaluations, was collected. Cytokines and adipocytokines plasmatic levels were determined using an ELISA method. Plasma leptin levels are in correlation with age (r=0.5; P<0.001) and BMI-z score (r=0.36; P<0.001), particularly in girls; plasma resistin levels are in inverse correlation with age, particularly in boys (r=-0.67; P<0.001) and in correlation with BMI-z score (r=0.52; P=0.002). Plasma leptin and resistin levels show a good correlation with antrophometric parameters of child obesity (sex and BMI z score). This study suggests that leptin and resistin can be considered as biomarker of childhood obesity and its comorbility. We observed a statistically significant correlation between plasma leptin and resistin levels and antrophometric parameters of child obesity (sex and BMI z score). This study suggests that adipocytokines, such as leptin and resistin, can be considered as biomarkers of childhood obesity.
Keywords: obesity; adipocytokines; inflammatory cytokines; BMI z-score obesity; adipocytokines; inflammatory cytokines; BMI z-score

Share and Cite

MDPI and ACS Style

Leoni, M.C.; Valsecchi, C.; Mantelli, M.; Marastoni, L.; Tinelli, C.; Marchi, A.; Castellazzi, A. Impact of Child Obesity on Adipose Tissue Physiology: Assessment of Adipocytokines and Inflammatory Cytokines as Biomarkers of Obesity. Pediatr. Rep. 2010, 2, e19. https://doi.org/10.4081/pr.2010.e19

AMA Style

Leoni MC, Valsecchi C, Mantelli M, Marastoni L, Tinelli C, Marchi A, Castellazzi A. Impact of Child Obesity on Adipose Tissue Physiology: Assessment of Adipocytokines and Inflammatory Cytokines as Biomarkers of Obesity. Pediatric Reports. 2010; 2(2):e19. https://doi.org/10.4081/pr.2010.e19

Chicago/Turabian Style

Leoni, Maria Chiara, Chiara Valsecchi, Melissa Mantelli, Laura Marastoni, Carmine Tinelli, Antonietta Marchi, and Annamaria Castellazzi. 2010. "Impact of Child Obesity on Adipose Tissue Physiology: Assessment of Adipocytokines and Inflammatory Cytokines as Biomarkers of Obesity" Pediatric Reports 2, no. 2: e19. https://doi.org/10.4081/pr.2010.e19

APA Style

Leoni, M. C., Valsecchi, C., Mantelli, M., Marastoni, L., Tinelli, C., Marchi, A., & Castellazzi, A. (2010). Impact of Child Obesity on Adipose Tissue Physiology: Assessment of Adipocytokines and Inflammatory Cytokines as Biomarkers of Obesity. Pediatric Reports, 2(2), e19. https://doi.org/10.4081/pr.2010.e19

Article Metrics

Back to TopTop