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Pediatric Reports
Volume 11
Issue 3
10.4081/pr.2019.8184
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Case Report

Giant Melanocytic Nevi and Soft Tissue Undergrowth in the Left Leg: Pathogenetic Hypothesis

by
Piero Pavone
1,
Raffaele Falsaperla
2,
Silvia Marino
2,*,
Martino Ruggieri
1,
Andrea D. Praticò
1 and
Beatrice Nardone
3
1
Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania
2
Unit of Pediatrics and Pediatric Emergency, University Hospital “Policlinico-Vittorio Emanuele”, University of Catania
3
Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, Catania University
4
Feinberg School of Medicine, Northwestern University, Chicago, IL
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2019, 11(3), 8184; https://doi.org/10.4081/pr.2019.8184
Submission received: 26 May 2019 / Revised: 26 May 2019 / Accepted: 3 June 2019 / Published: 20 June 2019

Abstract

Congenital melanocytic nevi (CMN) are observed frequently in children. The anomalous skin shows a widely variable clinical expression not only in the anatomic location, but also in color, morphology and superficial structure. According to the width CMN are distinguished in small, medium, large or giant. Aside the cosmetic problem and its psychological implications, CMN may present with severe complications consisting of malignant transformation and/or central nervous system involvement. We report on a 3-month old infant with an extensive CMN in the left leg, which extended from the lower portion of the knee to the foot, with satellite nevi. Concomitant with the extensive nevi in the same district a remarkable reduction in size was present, and involved the adipose and muscle tissues, contributing to a counterpart diameter difference of 5 cm, without bone involvement. Melanocytic nevi and soft tissue undergrowth in the leg is a usual association; a pathogenic explanation on the anomaly involving concomitantly the skin and the underneath soft tissues is advanced.
Keywords: cutaneous nevi; melanocytic; hypotrophic leg; congenital cutaneous nevi; melanocytic; hypotrophic leg; congenital

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MDPI and ACS Style

Pavone, P.; Falsaperla, R.; Marino, S.; Ruggieri, M.; Praticò, A.D.; Nardone, B. Giant Melanocytic Nevi and Soft Tissue Undergrowth in the Left Leg: Pathogenetic Hypothesis. Pediatr. Rep. 2019, 11, 8184. https://doi.org/10.4081/pr.2019.8184

AMA Style

Pavone P, Falsaperla R, Marino S, Ruggieri M, Praticò AD, Nardone B. Giant Melanocytic Nevi and Soft Tissue Undergrowth in the Left Leg: Pathogenetic Hypothesis. Pediatric Reports. 2019; 11(3):8184. https://doi.org/10.4081/pr.2019.8184

Chicago/Turabian Style

Pavone, Piero, Raffaele Falsaperla, Silvia Marino, Martino Ruggieri, Andrea D. Praticò, and Beatrice Nardone. 2019. "Giant Melanocytic Nevi and Soft Tissue Undergrowth in the Left Leg: Pathogenetic Hypothesis" Pediatric Reports 11, no. 3: 8184. https://doi.org/10.4081/pr.2019.8184

APA Style

Pavone, P., Falsaperla, R., Marino, S., Ruggieri, M., Praticò, A. D., & Nardone, B. (2019). Giant Melanocytic Nevi and Soft Tissue Undergrowth in the Left Leg: Pathogenetic Hypothesis. Pediatric Reports, 11(3), 8184. https://doi.org/10.4081/pr.2019.8184

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