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Pediatric Reports
Volume 11
Issue 2
10.4081/pr.2019.7997
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Article

Study of NT-pro-BNP and Hs-Troponin I Biomarkers for Early Detection of Children’s Heart Function of Protein-Energy Malnutrition

by
Herlina Dimiati
1,*,
Abdus Samik Wahab
2,
Mohammad Juffrie
2,
Madarina Julia
2 and
Basri A. Gani
3
1
Cardiology Division, Pediatric Health Department, Faculty of Medicine, Universitas Syiah Kuala-RSUZA Hospital, Banda Aceh
2
Pediatric Health Department, Faculty of Medicine, Gadjah Mada University, Yogyakarta
3
Oral Biology Department, Faculty of Dentistry, Universitas Syiah Kuala, Darussalam Banda Aceh
*
Author to whom correspondence should be addressed.
Pediatr. Rep. 2019, 11(2), 7997; https://doi.org/10.4081/pr.2019.7997
Submission received: 24 January 2019 / Revised: 11 April 2019 / Accepted: 11 April 2019 / Published: 23 May 2019

Abstract

The Protein Energy Malnutrition (PEM) is the condition of a lack of carbohydrate and protein stores in the body that trigger chronic failure nutrient intake and body maintenance function caused to impact the heart functions. The NT-pro-BNP and Hs- Troponin I proteins were found as the indicator of cardiac dysfunction. The sixty subjects of PEM, analyzed by standard of Indonesia Healt Ministry as well as nutritional status. The blood electrolytes examined by laboratory assay and the levels of Hs-Troponin 1 and NT-Pro-BNP were analyzed by Immune-Chromatography method. Assessing of the ventricular mass with the seeing the peak of the diastolic flow rate of left ventricular that estimated by the curve of the receiver operating characteristic and the area under the curve (P<0.05). The result has shown that the PEM decreased in the left ventricular mass for impaired heart function and systolic disorder. The Hs- Troponin I (90.9%) has better sensitivity than NT-pro-BNP (85.5%) if the merger of those markers possesses the lowest sensitivity (81.8%). These proteins have good biomarkers in heart function, mainly in cases where PEM is present.
Keywords: NT-Pro-BNP; Hs-Troponin I; left ventricle; protein-energy; malnutrition NT-Pro-BNP; Hs-Troponin I; left ventricle; protein-energy; malnutrition

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MDPI and ACS Style

Dimiati, H.; Wahab, A.S.; Juffrie, M.; Julia, M.; Gani, B.A. Study of NT-pro-BNP and Hs-Troponin I Biomarkers for Early Detection of Children’s Heart Function of Protein-Energy Malnutrition. Pediatr. Rep. 2019, 11, 7997. https://doi.org/10.4081/pr.2019.7997

AMA Style

Dimiati H, Wahab AS, Juffrie M, Julia M, Gani BA. Study of NT-pro-BNP and Hs-Troponin I Biomarkers for Early Detection of Children’s Heart Function of Protein-Energy Malnutrition. Pediatric Reports. 2019; 11(2):7997. https://doi.org/10.4081/pr.2019.7997

Chicago/Turabian Style

Dimiati, Herlina, Abdus Samik Wahab, Mohammad Juffrie, Madarina Julia, and Basri A. Gani. 2019. "Study of NT-pro-BNP and Hs-Troponin I Biomarkers for Early Detection of Children’s Heart Function of Protein-Energy Malnutrition" Pediatric Reports 11, no. 2: 7997. https://doi.org/10.4081/pr.2019.7997

APA Style

Dimiati, H., Wahab, A. S., Juffrie, M., Julia, M., & Gani, B. A. (2019). Study of NT-pro-BNP and Hs-Troponin I Biomarkers for Early Detection of Children’s Heart Function of Protein-Energy Malnutrition. Pediatric Reports, 11(2), 7997. https://doi.org/10.4081/pr.2019.7997

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