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First Insights into Clinical and Resistance Features of Infections by Klebsiella pneumoniae among Oncological Patients from a Referral Center in Amazon Region, Brazil

1
Parasite Biology in the Amazon Region (PPGBPA), Center of Biological and Health Sciences, State University of Pará (UEPA), Belém 66087-662, Brazil
2
Epidemiology and Health Surveillance (PPGEVS), Evandro Chagas Institute (IEC), Ananindeua 67030-000, Brazil
3
Bacteriology and Mycology Section, Evandro Chagas Institute (IEC), Ananindeua 67030-000, Brazil
*
Authors to whom correspondence should be addressed.
Infect. Dis. Rep. 2020, 12(3), 110-120; https://doi.org/10.3390/idr12030021
Received: 23 October 2020 / Revised: 14 November 2020 / Accepted: 16 November 2020 / Published: 3 December 2020
Klebsiella pneumoniae appears as one of the most prevalent pathogens among cancer patients. The present study investigates the clinical, epidemiological and microbiological aspects related to infections caused by K. pneumoniae in cancer patients treated at an oncology referral center in the state of Pará, Amazon region, Brazil. Between July 2017 to July 2019, an epidemiological, observational, cross-sectional study, with a descriptive and analytical approach was conducted, including patients with confirmed diagnosis of cancer who acquired infection by K. pneumoniae 72 h after hospital admission. K. pneumoniae isolates included in the study were obtained from different clinical materials (blood, urine, catheter tip and bladder catheter, orotracheal secretions, oncological and surgical wounds). Antimicrobial susceptibility testing and molecular detection of the carbapenemase-encoding genes were performed. A high prevalence of MDR K. pneumoniae isolates was observed, including two colistin-resistant isolates and seven isolates harboring blaKPC-1 gene. To conclude, our findings provide the firsts insights into the epidemiology and infection by K. pneumoniae in the state of Pará, Brazil, and may be useful on treatment guidance and establishment of strategies to control the spread of resistance strains of K. pneumoniae in the region. View Full-Text
Keywords: Klebsiella pneumoniae; neoplasms; multi-drug resistance; Brazil Klebsiella pneumoniae; neoplasms; multi-drug resistance; Brazil
MDPI and ACS Style

Santos, A.L.S.d.; Rodrigues, Y.C.; Melo, M.V.H.d.; Silva dos Santos, P.A.; Oliveira, T.N.d.C.; Sardinha, D.M.; Lima, L.N.G.C.; Brasiliense, D.M.; Lima, K.V.B. First Insights into Clinical and Resistance Features of Infections by Klebsiella pneumoniae among Oncological Patients from a Referral Center in Amazon Region, Brazil. Infect. Dis. Rep. 2020, 12, 110-120. https://doi.org/10.3390/idr12030021

AMA Style

Santos ALSd, Rodrigues YC, Melo MVHd, Silva dos Santos PA, Oliveira TNdC, Sardinha DM, Lima LNGC, Brasiliense DM, Lima KVB. First Insights into Clinical and Resistance Features of Infections by Klebsiella pneumoniae among Oncological Patients from a Referral Center in Amazon Region, Brazil. Infectious Disease Reports. 2020; 12(3):110-120. https://doi.org/10.3390/idr12030021

Chicago/Turabian Style

Santos, Anderson L.S.d.; Rodrigues, Yan C.; Melo, Marcos V.H.d.; Silva dos Santos, Pabllo A.; Oliveira, Tatyellen N.d.C.; Sardinha, Daniele M.; Lima, Luana N.G.C.; Brasiliense, Danielle M.; Lima, Karla V.B. 2020. "First Insights into Clinical and Resistance Features of Infections by Klebsiella pneumoniae among Oncological Patients from a Referral Center in Amazon Region, Brazil" Infect. Dis. Rep. 12, no. 3: 110-120. https://doi.org/10.3390/idr12030021

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