Next Article in Journal
Large Left Posterior Fossa Meningioma Presenting with Quadriplegia in a Woman with History of Carbidopa-Levodopa Resistant Parkinsonism
Previous Article in Journal
A Novel Homozygous Variation in the PANK2 Gene in Two Persian Siblings with Atypical Pantothenate Kinase Associated Neurodegeneration
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Neurology International
Volume 11
Issue 1
10.4081/ni.2019.7958
neurolint-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Case Report

Neuromyelitis Optic with Positive Anti-AQP4 and Anti-SSA/Ro Antibody

by
Riwanti Estiasari
1,*,
Salsabila Firdausia
1,
Dewi Wulandari
2,
Kartika Maharani
1,
Freddy Sitorus
1,
David Pangeran
1 and
Darma Imran
1
1
Department of Neurology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
2
Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia
*
Author to whom correspondence should be addressed.
Neurol. Int. 2019, 11(1), 7958; https://doi.org/10.4081/ni.2019.7958
Submission received: 29 November 2018 / Revised: 29 November 2018 / Accepted: 9 December 2018 / Published: 11 March 2019

Abstract

Neuromyelitis Optic (NMO) is an inflammatory disorder involving central nervous system which often co-exists with other autoimmune diseases such as Sjögren’s syndrome (SS). NMO manifestation could precede or follow SS, but the role of anti-SSA in the pathogenesis of NMO remains unclear. We present a case of NMO with anti-AQP4 anti-SSA antibody positive. A-44-year-old female presented with right side weakness. The symptoms began with numbness that improved spontaneously. She also complained pain and dry sensations on her eyes. Schirmer test on her left eye, antinuclear antibody (ANA) and anti- SSA antibody were positive. Cervical MRI revealed intramedullary lesion on T2- weighted-image at C2-C5 level. She was diagnosed as NMO with positive anti- AQP4 and probable SS. She received 1g methylprednisolone for 5 days proceeded with mycophenolic acid. One-year observation showed clinical improvement. Systemic autoantibodies must substantially be evaluated in NMO. Comprehensive diagnosis and providing appropriate immunosuppressant might prevent further disability and relapse.
Keywords: Neuromyelitis; Optic; Sjogren; AQP4; Anti-SSA Neuromyelitis; Optic; Sjogren; AQP4; Anti-SSA

Share and Cite

MDPI and ACS Style

Estiasari, R.; Firdausia, S.; Wulandari, D.; Maharani, K.; Sitorus, F.; Pangeran, D.; Imran, D. Neuromyelitis Optic with Positive Anti-AQP4 and Anti-SSA/Ro Antibody. Neurol. Int. 2019, 11, 7958. https://doi.org/10.4081/ni.2019.7958

AMA Style

Estiasari R, Firdausia S, Wulandari D, Maharani K, Sitorus F, Pangeran D, Imran D. Neuromyelitis Optic with Positive Anti-AQP4 and Anti-SSA/Ro Antibody. Neurology International. 2019; 11(1):7958. https://doi.org/10.4081/ni.2019.7958

Chicago/Turabian Style

Estiasari, Riwanti, Salsabila Firdausia, Dewi Wulandari, Kartika Maharani, Freddy Sitorus, David Pangeran, and Darma Imran. 2019. "Neuromyelitis Optic with Positive Anti-AQP4 and Anti-SSA/Ro Antibody" Neurology International 11, no. 1: 7958. https://doi.org/10.4081/ni.2019.7958

APA Style

Estiasari, R., Firdausia, S., Wulandari, D., Maharani, K., Sitorus, F., Pangeran, D., & Imran, D. (2019). Neuromyelitis Optic with Positive Anti-AQP4 and Anti-SSA/Ro Antibody. Neurology International, 11(1), 7958. https://doi.org/10.4081/ni.2019.7958

Article Metrics

Back to TopTop