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Neurology International
Volume 10
Issue 4
10.4081/ni.2018.7917
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Accuracy of B-natriuretic Peptide for the Diagnosis of Decompensated Heart Failure in Muscular Dystrophies Patients with Chronic Respiratory Failure

by
Paris Meng
1,
Lee S. Nguyen
2,
Firas Jabbour
3,
Adam Ogna
1,
Bernard Clair
1,
David Orlikowski
1,4,
Djillali Annane
1,
Frederic Lofaso
5 and
Abdallah Fayssoil
1,6,*
1
Service of Medical Resuscitation, Home Ventilation Unit, Raymond Poincaré, University of Versailles Saint Quentin en Yvelines, Garches, France
2
Center of Clinical Investigation Paris-Est, Pitié Salpetrière, Sorbonne University, Paris, France
3
Biochemistry Department, Raymond Poincaré, University of Versailles Saint Quentin en Yvelines, Garches, France
4
Clinical Investigation and Technological Innovation Centre, INSERM, Garches, France
5
Physiology Department - Functional Explorations, Raymond Poincaré, University of Versailles Saint Quentin en Yvelines, Garches, France
6
Institute of Myology, Pitié Salpetrière, Paris, France
*
Author to whom correspondence should be addressed.
Neurol. Int. 2018, 10(4), 7917; https://doi.org/10.4081/ni.2018.7917
Submission received: 27 October 2018 / Revised: 27 October 2018 / Accepted: 19 November 2018 / Published: 20 December 2018

Abstract

Heart failure and restrictive respiratory insufficiency are complications in muscular dystrophies. We aimed to assess the accuracy of the B-natriuretic peptide (BNP) for the diagnosis of decompensated heart failure in muscular dystrophy. We included patients with muscular dystrophy and chronic respiratory insufficiency admitted in the Intensive Care Unit of the Raymond Poincare hospital (Garches, France) for suspected decompensated heart failure. Thirtyseven patients were included, among them, 23 Duchenne muscular dystrophy (DMD) (62%), 10 myotonic dystrophy type 1(DM1) (27%). Median age was 35 years [27.5; 48.5]. 86.5% of patients were on home mechanical ventilation (HMV). Median left ventricular ejection fraction (LVEF) was 47% [35.0; 59.5]. Median BNP blood level was 104 pg/mL [50; 399]. The BNP level was significantly inversely associated with LVEF (r= –0.37, p 0.03) and positively associated with the LVEDD (left ventricular end diastolic diameter) (r=0.59, P<0.001). The discriminative value of the BNP level for the diagnosis of decompensated heart failure was high with an AUROC=0.94 (P<0.001). The best discriminating BNP threshold was 307 pg/mL (Youden index 0.85). The BNP level measurement may add a supplemental key for the final diagnosis of decompensated heart failure.
Keywords: BNP; heart failure; muscular dystrophy BNP; heart failure; muscular dystrophy

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MDPI and ACS Style

Meng, P.; Nguyen, L.S.; Jabbour, F.; Ogna, A.; Clair, B.; Orlikowski, D.; Annane, D.; Lofaso, F.; Fayssoil, A. Accuracy of B-natriuretic Peptide for the Diagnosis of Decompensated Heart Failure in Muscular Dystrophies Patients with Chronic Respiratory Failure. Neurol. Int. 2018, 10, 7917. https://doi.org/10.4081/ni.2018.7917

AMA Style

Meng P, Nguyen LS, Jabbour F, Ogna A, Clair B, Orlikowski D, Annane D, Lofaso F, Fayssoil A. Accuracy of B-natriuretic Peptide for the Diagnosis of Decompensated Heart Failure in Muscular Dystrophies Patients with Chronic Respiratory Failure. Neurology International. 2018; 10(4):7917. https://doi.org/10.4081/ni.2018.7917

Chicago/Turabian Style

Meng, Paris, Lee S. Nguyen, Firas Jabbour, Adam Ogna, Bernard Clair, David Orlikowski, Djillali Annane, Frederic Lofaso, and Abdallah Fayssoil. 2018. "Accuracy of B-natriuretic Peptide for the Diagnosis of Decompensated Heart Failure in Muscular Dystrophies Patients with Chronic Respiratory Failure" Neurology International 10, no. 4: 7917. https://doi.org/10.4081/ni.2018.7917

APA Style

Meng, P., Nguyen, L. S., Jabbour, F., Ogna, A., Clair, B., Orlikowski, D., Annane, D., Lofaso, F., & Fayssoil, A. (2018). Accuracy of B-natriuretic Peptide for the Diagnosis of Decompensated Heart Failure in Muscular Dystrophies Patients with Chronic Respiratory Failure. Neurology International, 10(4), 7917. https://doi.org/10.4081/ni.2018.7917

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