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Volume 1
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10.4081/ni.2009.e18
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Granulomatous Hypophysitis by Mycobacterium Gordonae in a Non Hiv-Infected Patient

by
Juan José Padilla-Martínez
1,
Salvador González-Cornejo
1,
Lucía Elizabeth Álvarez-Palazuelos
1,
Jesús Alejandro Villagómez-Méndez
1,
Erwin Chiquete
2,
José Alfredo Domínguez-Rosales
3,4,
Ismael Espejo-Plascencia
3,
Esteban González-Díaz
5,
José Rodrigo Torres-Baranda
6 and
José Luis Ruiz-Sandoval
7,*
1
Department of Neurology and Neurosurgery, from the Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Mexico
2
Department of Internal Medicine; from the Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Mexico
3
Department of Pathology, from the Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Mexico
4
Department of Molecular Biology, from the Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Mexico
5
Department of Infectious Diseases, from the Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Mexico
6
Department of Molecular Biology and Genomics, from the Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Jalisco, Mexico
7
Department of Neurosciences, from the Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Jalisco, Mexico
*
Author to whom correspondence should be addressed.
Neurol. Int. 2009, 1(1), e18; https://doi.org/10.4081/ni.2009.e18
Submission received: 10 October 2009 / Accepted: 19 October 2009 / Published: 14 December 2009

Abstract

Lymphocytic or granulomatous hypophysitis is a rare entity with a difficult diagnosis. Our objective was to report a patient with non-tuberculous granulomatous hypophysitis. An HIV-negative 45-year old man with confusional state, subacute ophthalmoplegia, and clinical and laboratory findings of panhypopituitarism was seen in the emergency unit. A cranial MRI showed a sellar mass suggestive of hypophysitis. After an unsuccessful attempt with steroids and antituberculous drugs the patient died. Post-mortem histopathology revealed granulomatous lesions and restriction fragment length polymorphism analysis confirmed the presence of Mycobacterium gordonae’s DNA. In conclusion, we should consider granulomatous hypophysitis in the differential diagnosis of non-secreting hypophyseal tumors. The etiology of a pituitary granuloma by a non-tuberculous mycobacteria is best reached by histopathological techniques and molecular assays. The optimal therapy is yet to be established.
Keywords: granuloma; hypophysis; nontuberculous mycobacteria; panhypopitituarism; pituitary gland. granuloma; hypophysis; nontuberculous mycobacteria; panhypopitituarism; pituitary gland.

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MDPI and ACS Style

Padilla-Martínez, J.J.; González-Cornejo, S.; Álvarez-Palazuelos, L.E.; Villagómez-Méndez, J.A.; Chiquete, E.; Domínguez-Rosales, J.A.; Espejo-Plascencia, I.; González-Díaz, E.; Torres-Baranda, J.R.; Ruiz-Sandoval, J.L. Granulomatous Hypophysitis by Mycobacterium Gordonae in a Non Hiv-Infected Patient. Neurol. Int. 2009, 1, e18. https://doi.org/10.4081/ni.2009.e18

AMA Style

Padilla-Martínez JJ, González-Cornejo S, Álvarez-Palazuelos LE, Villagómez-Méndez JA, Chiquete E, Domínguez-Rosales JA, Espejo-Plascencia I, González-Díaz E, Torres-Baranda JR, Ruiz-Sandoval JL. Granulomatous Hypophysitis by Mycobacterium Gordonae in a Non Hiv-Infected Patient. Neurology International. 2009; 1(1):e18. https://doi.org/10.4081/ni.2009.e18

Chicago/Turabian Style

Padilla-Martínez, Juan José, Salvador González-Cornejo, Lucía Elizabeth Álvarez-Palazuelos, Jesús Alejandro Villagómez-Méndez, Erwin Chiquete, José Alfredo Domínguez-Rosales, Ismael Espejo-Plascencia, Esteban González-Díaz, José Rodrigo Torres-Baranda, and José Luis Ruiz-Sandoval. 2009. "Granulomatous Hypophysitis by Mycobacterium Gordonae in a Non Hiv-Infected Patient" Neurology International 1, no. 1: e18. https://doi.org/10.4081/ni.2009.e18

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