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Cardiogenetics
Volume 1
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10.4081/cardiogenetics.2011.s1.e6
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Review

Sudden Infant Death Syndrome and Cardiac Channelopathies: From Mechanisms to Prevention of Avoidable Tragedies

by
Roberto Insolia
1,2,
Alice Ghidoni
1,2,
Cinzia Dossena
2,
Elisa Mastantuono
2 and
Peter J. Schwartz
1,2,3,4,5,*
1
Department of Molecular Medicine, University of Pavia, Italy; Laboratory of Molecular Cardiology, Fondazione IRCCS Policlinico S. Matteo, Pavia
2
Laboratory of Molecular Cardiology, Fondazione IRCCS Policlinico S. Matteo, Pavia
3
Department of Cardiology, Fondazione IRCCS Policlinico S. Matteo, Pavia
4
Cardiovascular Genetics Laboratory, Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, University of Cape Town
5
Chair of Sudden Death, Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia
*
Author to whom correspondence should be addressed.
Cardiogenetics 2011, 1(s1), e6; https://doi.org/10.4081/cardiogenetics.2011.s1.e6
Submission received: 14 November 2011 / Revised: 14 November 2011 / Accepted: 15 November 2011 / Published: 20 November 2011

Abstract

The sudden infant death syndrome (SIDS), with the load of mystery surrounding its causes and with the devastating impact on the affected families, remains the greatest contributor to post-neonatal mortality during the first year of life. Following a succinct review of the non-cardiac genetic factors, which have been associated with SIDS, we focus on the cardiac hypothesis for SIDS and specifically on those diseases produced by cardiac ion channel mutations, the so-called channelopathies. Special attention is devoted to the fact that these causes of SIDS, and especially the long QT syndrome, are preventable if diagnosed in time. This highlights the importance of neonatal ECG screening and carries a number of practical implications, including medico-legal considerations.
Keywords: SIDS; sudden infant death syndrome; post-neonatal mortality SIDS; sudden infant death syndrome; post-neonatal mortality

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MDPI and ACS Style

Insolia, R.; Ghidoni, A.; Dossena, C.; Mastantuono, E.; Schwartz, P.J. Sudden Infant Death Syndrome and Cardiac Channelopathies: From Mechanisms to Prevention of Avoidable Tragedies. Cardiogenetics 2011, 1, e6. https://doi.org/10.4081/cardiogenetics.2011.s1.e6

AMA Style

Insolia R, Ghidoni A, Dossena C, Mastantuono E, Schwartz PJ. Sudden Infant Death Syndrome and Cardiac Channelopathies: From Mechanisms to Prevention of Avoidable Tragedies. Cardiogenetics. 2011; 1(s1):e6. https://doi.org/10.4081/cardiogenetics.2011.s1.e6

Chicago/Turabian Style

Insolia, Roberto, Alice Ghidoni, Cinzia Dossena, Elisa Mastantuono, and Peter J. Schwartz. 2011. "Sudden Infant Death Syndrome and Cardiac Channelopathies: From Mechanisms to Prevention of Avoidable Tragedies" Cardiogenetics 1, no. s1: e6. https://doi.org/10.4081/cardiogenetics.2011.s1.e6

APA Style

Insolia, R., Ghidoni, A., Dossena, C., Mastantuono, E., & Schwartz, P. J. (2011). Sudden Infant Death Syndrome and Cardiac Channelopathies: From Mechanisms to Prevention of Avoidable Tragedies. Cardiogenetics, 1(s1), e6. https://doi.org/10.4081/cardiogenetics.2011.s1.e6

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