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Cardiogenetics
Volume 1
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10.4081/cardiogenetics.2011.s1.e1
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Cardiogenetics is published by MDPI from Volume 10 Issue 2 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Editorial

Ion Channels and Beating Heart: The Players and the Music

by
Lia Crotti
1,2,3,*,
Giuseppe Limongelli
4 and
Charles Antzelevitch
5
1
Department of Molecular Medicine, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy
2
Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
3
Institute of Human Genetics, Helmholtz Center Munich, Neuherberg, Germany
4
Second University of Naples, Monaldi Hospital, Naples, Italy
5
Masonic Medical Research Laboratory, Utica, New York, USA
*
Author to whom correspondence should be addressed.
Cardiogenetics 2011, 1(s1), e1; https://doi.org/10.4081/cardiogenetics.2011.s1.e1
Submission received: 10 November 2011 / Revised: 20 November 2011 / Accepted: 20 November 2011 / Published: 20 November 2011

Abstract

Soft gentle music accompanies us throughout our lifetime; it is the music of our heart beating. Although at times it is questionable as to who serves as conductor of the orchestra, there is little doubt that our ion channels are the main players. Whenever one of them plays too loudly, too softly or simply off key, disharmony results, sometimes leading to total disruption of the rate and rhythm. Ion channels can disrupt the music of our heart by different mechanisms. Sometimes their function is correct, but their expression is altered by underlying cardiac diseases (i.e. heart failure); sometimes the defect is in their structure, because of an underlying genetic defect, and in this case a channelopathy is present.
Keywords: ion channels; cardiogenetics; channelopathy ion channels; cardiogenetics; channelopathy

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MDPI and ACS Style

Crotti, L.; Limongelli, G.; Antzelevitch, C. Ion Channels and Beating Heart: The Players and the Music. Cardiogenetics 2011, 1, e1. https://doi.org/10.4081/cardiogenetics.2011.s1.e1

AMA Style

Crotti L, Limongelli G, Antzelevitch C. Ion Channels and Beating Heart: The Players and the Music. Cardiogenetics. 2011; 1(s1):e1. https://doi.org/10.4081/cardiogenetics.2011.s1.e1

Chicago/Turabian Style

Crotti, Lia, Giuseppe Limongelli, and Charles Antzelevitch. 2011. "Ion Channels and Beating Heart: The Players and the Music" Cardiogenetics 1, no. s1: e1. https://doi.org/10.4081/cardiogenetics.2011.s1.e1

APA Style

Crotti, L., Limongelli, G., & Antzelevitch, C. (2011). Ion Channels and Beating Heart: The Players and the Music. Cardiogenetics, 1(s1), e1. https://doi.org/10.4081/cardiogenetics.2011.s1.e1

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