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Review

Genetics of Cardiomyopathies in Children

1
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
2
The Heart Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
*
Author to whom correspondence should be addressed.
Cardiogenetics 2011, 1(1), e9; https://doi.org/10.4081/cardiogenetics.2011.e9
Received: 16 May 2011 / Revised: 16 May 2011 / Accepted: 20 July 2011 / Published: 17 August 2011

Abstract

Cardiomyopathies are diseases of the heart muscle leading to heart failure and/or an increased risk of arrhythmogenic sudden cardiac death. These disorders represent a major cause of morbidity and mortality in children. In childhood forms of cardiomyopathy, genetic etiologies are frequent, but non-genetic or acquired causes, such viral infection, also play a significant role. In the last twenty years, the genetic causes of cardiomyopathies have been increasingly identified and clinical correlations are beginning to be defined. Here we present an overview of the recent advances in our understanding of the genetics of cardiomyopathies in children and what is known about the pathophysiological mechanisms underlying these gene-related forms of disease.
Keywords: sudden cardiac death; dilated cardiomyopathy; hypertrophic cardiomyopathy; left ventricular noncompaction; restrictive cardiomyopathy; arrhythmogenic right ventricular cardiomyopathy; Nav1.5; LQTS; ion channels sudden cardiac death; dilated cardiomyopathy; hypertrophic cardiomyopathy; left ventricular noncompaction; restrictive cardiomyopathy; arrhythmogenic right ventricular cardiomyopathy; Nav1.5; LQTS; ion channels

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MDPI and ACS Style

Vatta, M.; Towbin, J.A. Genetics of Cardiomyopathies in Children. Cardiogenetics 2011, 1, e9. https://doi.org/10.4081/cardiogenetics.2011.e9

AMA Style

Vatta M, Towbin JA. Genetics of Cardiomyopathies in Children. Cardiogenetics. 2011; 1(1):e9. https://doi.org/10.4081/cardiogenetics.2011.e9

Chicago/Turabian Style

Vatta, Matteo, and Jeffrey A. Towbin. 2011. "Genetics of Cardiomyopathies in Children" Cardiogenetics 1, no. 1: e9. https://doi.org/10.4081/cardiogenetics.2011.e9

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