Next Article in Journal
Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats
Previous Article in Journal / Special Issue
Drug Development for Pediatric Populations: Regulatory Aspects

Pediatric Dosing and Body Size in Biotherapeutics

Department of Pharmaceutics, University of Florida, Gainesville, FL, 32610, USA
Author to whom correspondence should be addressed.
Pharmaceutics 2010, 2(4), 389-418;
Received: 26 October 2010 / Revised: 9 December 2010 / Accepted: 15 December 2010 / Published: 16 December 2010
Although pediatric doses for biotherapeutics are often based on patients' body weight (mg/kg) or body surface area (mg/m2), linear body size dose adjustment is highly empirical. Growth and maturity are also important factors that affect the absorption, distribution, metabolism and excretion (ADME) of biologics in pediatrics. The complexity of the factors involved in pediatric pharmacokinetics lends to the reconsideration of body size based dose adjustment. A proper dosing adjustment for pediatrics should also provide less intersubject variability in the pharmacokinetics and/or pharmacodynamics of the product compared with no dose adjustment. Biological proteins and peptides generally share the same pharmacokinetic principle with small molecules, but the underlying mechanism can be very different. Here, pediatric and adult pharmacokinetic parameters are compared and summarized for selected biotherapeutics. The effect of body size on the pediatric pharmacokinetics for these biological products is discussed in the current review. View Full-Text
Keywords: pediatric; dosing; proteins; peptides pediatric; dosing; proteins; peptides
Show Figures

Figure 1

MDPI and ACS Style

Shi, R.; Derendorf, H. Pediatric Dosing and Body Size in Biotherapeutics. Pharmaceutics 2010, 2, 389-418.

AMA Style

Shi R, Derendorf H. Pediatric Dosing and Body Size in Biotherapeutics. Pharmaceutics. 2010; 2(4):389-418.

Chicago/Turabian Style

Shi, Rong, and Hartmut Derendorf. 2010. "Pediatric Dosing and Body Size in Biotherapeutics" Pharmaceutics 2, no. 4: 389-418.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop