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Article

Opening the Blood Brain Barrier with an Electropermanent Magnet System

1
Weinberg Medical Physics, Inc., North Bethesda, MD 20852, USA
2
Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA
3
Center for Translational Imaging, Georgetown University Medical Center, Washington, DC 20057, USA
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Department of Radiology, Georgetown University Medical Center, Washington, DC 20057, USA
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Independent Consultant, Oklahoma City, OK 73134, USA
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Department of Management Science and Information Systems, Oklahoma State University, Stillwater, OK 74078, USA
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ACUITYnano LLC, Chevy Chase, MD 20815, USA
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Department of Electrical and Computer Engineering, University of Florida, Gainesville, FL 32611, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Vibhuti Agrahari and Prashant Kumar
Pharmaceutics 2022, 14(7), 1503; https://doi.org/10.3390/pharmaceutics14071503
Received: 2 July 2022 / Revised: 15 July 2022 / Accepted: 18 July 2022 / Published: 20 July 2022
(This article belongs to the Special Issue Novel Approaches for Overcoming Biological Barriers)
Opening the blood brain barrier (BBB) under imaging guidance may be useful for the treatment of many brain disorders. Rapidly applied magnetic fields have the potential to generate electric fields in brain tissue that, if properly timed, may enable safe and effective BBB opening. By tuning magnetic pulses generated by a novel electropermanent magnet (EPM) array, we demonstrate the opening of tight junctions in a BBB model culture in vitro, and show that induced monophasic electrical pulses are more effective than biphasic ones. We confirmed, with in vivo contrast-enhanced MRI, that the BBB can be opened with monophasic pulses. As electropermanent magnets have demonstrated efficacy at tuning B0 fields for magnetic resonance imaging studies, our results suggest the possibility of implementing an EPM-based hybrid theragnostic device that could both image the brain and enhance drug transport across the BBB in a single sitting. View Full-Text
Keywords: blood brain barrier; electropermanent magnet; magnetic resonance imaging blood brain barrier; electropermanent magnet; magnetic resonance imaging
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MDPI and ACS Style

Jafari, S.; Baum, I.S.; Udalov, O.G.; Lee, Y.; Rodriguez, O.; Fricke, S.T.; Jafari, M.; Amini, M.; Probst, R.; Tang, X.; Chen, C.; Ariando, D.J.; Hevaganinge, A.; Mair, L.O.; Albanese, C.; Weinberg, I.N. Opening the Blood Brain Barrier with an Electropermanent Magnet System. Pharmaceutics 2022, 14, 1503. https://doi.org/10.3390/pharmaceutics14071503

AMA Style

Jafari S, Baum IS, Udalov OG, Lee Y, Rodriguez O, Fricke ST, Jafari M, Amini M, Probst R, Tang X, Chen C, Ariando DJ, Hevaganinge A, Mair LO, Albanese C, Weinberg IN. Opening the Blood Brain Barrier with an Electropermanent Magnet System. Pharmaceutics. 2022; 14(7):1503. https://doi.org/10.3390/pharmaceutics14071503

Chicago/Turabian Style

Jafari, Sahar, Ittai S. Baum, Oleg G. Udalov, Yichien Lee, Olga Rodriguez, Stanley T. Fricke, Maryam Jafari, Mostafa Amini, Roland Probst, Xinyao Tang, Cheng Chen, David J. Ariando, Anjana Hevaganinge, Lamar O. Mair, Christopher Albanese, and Irving N. Weinberg. 2022. "Opening the Blood Brain Barrier with an Electropermanent Magnet System" Pharmaceutics 14, no. 7: 1503. https://doi.org/10.3390/pharmaceutics14071503

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