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BUB3, beyond the Simple Role of Partner

1
UNIPRO—Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), University Polytechnic Higher Education Cooperative (CESPU), Rua Central de Gandra, 4585-116 Gandra, Portugal
2
TOXRUN—Toxicology Research Unit, University Institute of Health Sciences (IUCS), University Polytechnic Higher Education Cooperative (CESPU), Rua Central de Gandra, 4585-116 Gandra, Portugal
3
Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Terminal de Cruzeiros do Porto de Leixões, Av. General Norton de Matos s/n, 4450-208 Matosinhos, Portugal
*
Author to whom correspondence should be addressed.
Academic Editor: Carlo Irace
Pharmaceutics 2022, 14(5), 1084; https://doi.org/10.3390/pharmaceutics14051084
Received: 31 March 2022 / Revised: 12 May 2022 / Accepted: 16 May 2022 / Published: 18 May 2022
(This article belongs to the Special Issue Novel Anticancer Strategies (Volume II))
The BUB3 protein plays a key role in the activation of the spindle assembly checkpoint (SAC), a ubiquitous surveillance mechanism that ensures the fidelity of chromosome segregation in mitosis and, consequently, prevents chromosome mis-segregation and aneuploidy. Besides its role in SAC signaling, BUB3 regulates chromosome attachment to the spindle microtubules. It is also involved in telomere replication and maintenance. Deficiency of the BUB3 gene has been closely linked to premature aging. Upregulation of the BUB3 gene has been found in a variety of human cancers and is associated with poor prognoses. Here, we review the structure and functions of BUB3 in mitosis, its expression in cancer and association with survival prognoses, and its potential as an anticancer target. View Full-Text
Keywords: BUB3; spindle assembly checkpoint; mitosis; cancer; senescence; anticancer target BUB3; spindle assembly checkpoint; mitosis; cancer; senescence; anticancer target
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MDPI and ACS Style

Silva, P.M.A.; Bousbaa, H. BUB3, beyond the Simple Role of Partner. Pharmaceutics 2022, 14, 1084. https://doi.org/10.3390/pharmaceutics14051084

AMA Style

Silva PMA, Bousbaa H. BUB3, beyond the Simple Role of Partner. Pharmaceutics. 2022; 14(5):1084. https://doi.org/10.3390/pharmaceutics14051084

Chicago/Turabian Style

Silva, Patrícia M.A., and Hassan Bousbaa. 2022. "BUB3, beyond the Simple Role of Partner" Pharmaceutics 14, no. 5: 1084. https://doi.org/10.3390/pharmaceutics14051084

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