Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration
1
Institute of Translational Medicine, Shanghai University, Shanghai 200444, China
2
School of Medicine, Shanghai University, Shanghai 200444, China
3
School of Life Sciences, Shanghai University, Shanghai 200444, China
4
Department of Orthopedics, Shanghai Zhongye Hospital, Shanghai 200941, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Academic Editors: Joaquim Miguel Oliveira, Rui L. Reis and Viviana Pinto Ribeiro
Pharmaceutics 2022, 14(5), 1069; https://doi.org/10.3390/pharmaceutics14051069
Received: 1 April 2022
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Revised: 1 May 2022
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Accepted: 13 May 2022
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Published: 17 May 2022
(This article belongs to the Special Issue Tissue Engineered Biomaterials and Drug Delivery Systems)
Titanium and its alloys are the most widely applied orthopedic and dental implant materials due to their high biocompatibility, superior corrosion resistance, and outstanding mechanical properties. However, the lack of superior osseointegration remains the main obstacle to successful implantation. Previous traditional surface modification methods of titanium-based implants cannot fully meet the clinical needs of osseointegration. The construction of local drug delivery systems (e.g., antimicrobial drug delivery systems, anti-bone resorption drug delivery systems, etc.) on titanium-based implants has been proved to be an effective strategy to improve osseointegration. Meanwhile, these drug delivery systems can also be combined with traditional surface modification methods, such as anodic oxidation, acid etching, surface coating technology, etc., to achieve desirable and enhanced osseointegration. In this paper, we review the research progress of different local drug delivery systems using titanium-based implants and provide a theoretical basis for further research on drug delivery systems to promote bone–implant integration in the future.
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Keywords:
local drug delivery system; titanium; bone healing; osseointegration; surface modification
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MDPI and ACS Style
Meng, F.; Yin, Z.; Ren, X.; Geng, Z.; Su, J. Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration. Pharmaceutics 2022, 14, 1069. https://doi.org/10.3390/pharmaceutics14051069
AMA Style
Meng F, Yin Z, Ren X, Geng Z, Su J. Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration. Pharmaceutics. 2022; 14(5):1069. https://doi.org/10.3390/pharmaceutics14051069
Chicago/Turabian StyleMeng, Fanying, Zhifeng Yin, Xiaoxiang Ren, Zhen Geng, and Jiacan Su. 2022. "Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration" Pharmaceutics 14, no. 5: 1069. https://doi.org/10.3390/pharmaceutics14051069
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