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Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations

Laboratory of Drug Development, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil
Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Granada, Campus of Cartuja s/n, 18071 Granada, Spain
Andalusian Institute of Earth Sciences, CSIC-University of Granada, Av. de las Palmeras 4, Armilla, 18100 Granada, Spain
Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
Authors to whom correspondence should be addressed.
Academic Editors: Maria Camilla Bergonzi and Bozena B. Michniak-Kohn
Pharmaceutics 2022, 14(5), 1067;
Received: 28 February 2022 / Revised: 15 April 2022 / Accepted: 26 April 2022 / Published: 17 May 2022
(This article belongs to the Special Issue Special Issue in Honor of Professor Carla Caramella)
Nanocomposites formed by clay and lipid carriers (NLCs) show a high potential for providing controlled release and specific delivery of bioactive molecules and have recently gained attention in the pharmaceutical sector due to their ability to transport hydrophilic and hydrophobic drugs. Recent studies have recognized the biological activity of the oil of Bixa orellana L. (AO) with regards to its healing, antioxidant, antibacterial, and anti-leishmanial properties. Therefore, the purpose of this study is the preparation and characterization of hybrid systems based on lipid nanocarriers and laponite for the delivery of AO. NLCs were prepared by the fusion-emulsification method, using cetyl palmitate (CP) or myristyl myristate (MM), AO, and Poloxamer 188. The morphology, hydrodynamic diameters, zeta potential (ZP), polydispersity index (PDI), thermal analysis, X-ray diffraction analysis (XRD), viscosity behavior, and cytotoxicity testing of the hybrid systems were performed. The thermal study and X-ray diffraction analyses (XRD) revealed polymorphic structural changes compatible with the amorphization of the material. Rheological assays highlighted a typical pseudoplastic behavior in all systems (MM and CP with LAP). The hybrid systems’ morphology, size diameters, and PDIs were similar, preset spherical and monodisperse structures (≈200 nm; <0.3), without significant change up to sixty days. The ZP values differed from each other, becoming higher with increasing AO concentration. XEDS spectra and elemental X-ray maps show peaks of lipids (organic components, C and O) and inorganic components O, Mg, and Si. All samples showed cell viability above 60%. The results indicated a stable, biocompatible hybrid system that can be an alternative for topical application. View Full-Text
Keywords: hybrid system; topical formulations; colloidal suspension; Bixa orellana L. hybrid system; topical formulations; colloidal suspension; Bixa orellana L.
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MDPI and ACS Style

Barbosa, R.d.M.; Leite, A.M.; García-Villén, F.; Sánchez-Espejo, R.; Cerezo, P.; Viseras, C.; Faccendini, A.; Sandri, G.; Raffin, F.N.; Moura, T.F.A.d.L.e. Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations. Pharmaceutics 2022, 14, 1067.

AMA Style

Barbosa RdM, Leite AM, García-Villén F, Sánchez-Espejo R, Cerezo P, Viseras C, Faccendini A, Sandri G, Raffin FN, Moura TFAdLe. Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations. Pharmaceutics. 2022; 14(5):1067.

Chicago/Turabian Style

Barbosa, Raquel de Melo, Aliana Monteiro Leite, Fátima García-Villén, Rita Sánchez-Espejo, Pilar Cerezo, César Viseras, Angela Faccendini, Giuseppina Sandri, Fernanda Nervo Raffin, and Túlio Flávio Accioly de Lima e Moura. 2022. "Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations" Pharmaceutics 14, no. 5: 1067.

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