Recent Applications of Contact Lenses for Bacterial Corneal Keratitis Therapeutics: A Review
Abstract
:1. Introduction
2. Diagnosis of Bacterial Keratitis
2.1. Traditional Colony Culture Investigation
2.2. Corneal Imaging
2.3. Molecular Detection
2.4. Signs and Symptoms
2.5. Traditional Treatments
3. Contact Lenses for Corneal Keratitis
3.1. CL Hydrogel Types
3.2. Antibacterial CLs
3.2.1. Applying Antibacterial Agents in CLs
Embedded Nanomaterials in CLs
- Silver nanoparticles
- Gold nanoparticles
- Zinc oxide nanoparticles
Integration of Antibacterial Peptides with CLs
ROS Produce Reagents for Bacterial Killing
3.2.2. Prevention of Bacterial Adherence to CLs
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Material | Molecular Formula | Advantages | Disadvantages | Reference(s) | |
---|---|---|---|---|---|
Hard CLs | PMMA | (C5H8O2)n | Excellent optical properties, high toughness, rigid, inexpensive | Low gas permeability, limited hydrophilic ability, inflexible | [16,17] |
PET | (C10H8O4)n | Outstanding chemical and thermal resistance, inexpensive | Low hydrophobic ability, glass transition temperature, rigidity, and surface energy | [16] | |
Soft CLs | MPC | C11H22NO6P | Good surface wettability, high gas permeability, low protein adsorption, and inexpensive | Low mechanical strength | [17] |
PDMS | (C2H6OSi)n | High gas permeability, inexpensive | Limited wearability | [16,18] | |
HEMA | (C6H10O3)n | High water content, good chemical and thermal stability, high hydrophobic ability, flexibility, gas permeability, biocompatibility, and inexpensive | Low gas permeability, protein deposition issues | [16] | |
Silicone | (R2SiO)n | High gas permeability | Highly hydrophobic, expensive | [19] |
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Nie, L.; Li, Y.; Liu, Y.; Shi, L.; Chen, H. Recent Applications of Contact Lenses for Bacterial Corneal Keratitis Therapeutics: A Review. Pharmaceutics 2022, 14, 2635. https://doi.org/10.3390/pharmaceutics14122635
Nie L, Li Y, Liu Y, Shi L, Chen H. Recent Applications of Contact Lenses for Bacterial Corneal Keratitis Therapeutics: A Review. Pharmaceutics. 2022; 14(12):2635. https://doi.org/10.3390/pharmaceutics14122635
Chicago/Turabian StyleNie, Linyan, Yuanfeng Li, Yong Liu, Linqi Shi, and Huiyun Chen. 2022. "Recent Applications of Contact Lenses for Bacterial Corneal Keratitis Therapeutics: A Review" Pharmaceutics 14, no. 12: 2635. https://doi.org/10.3390/pharmaceutics14122635