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Peer-Review Record

Microrobot with Gyroid Surface and Gold Nanostar for High Drug Loading and Near-Infrared-Triggered Chemo-Photothermal Therapy

Pharmaceutics 2022, 14(11), 2393; https://doi.org/10.3390/pharmaceutics14112393
by Shirong Zheng 1,2,3, Manh Cuong Hoang 3, Van Du Nguyen 2,3, Gwangjun Go 2,3, Minghui Nan 2,3, Bobby Aditya Darmawan 3, Seokjae Kim 1,3, Seung-hyun Im 3, Taeksu Lee 3,*, Doyeon Bang 2,3,4,5, Jong-Oh Park 1,3 and Eunpyo Choi 1,2,3,*
Reviewer 1: Anonymous
Reviewer 2:
Pharmaceutics 2022, 14(11), 2393; https://doi.org/10.3390/pharmaceutics14112393
Submission received: 13 October 2022 / Revised: 31 October 2022 / Accepted: 3 November 2022 / Published: 6 November 2022

Round 1

Reviewer 1 Report

The manuscript reported microrobot with gyroid surface and gold nanostar for chemo-photothermal therapy. However, the design of the application is defective. In my opinion, major revisions is necessary before pulication.

1.     Can you ensure the gold nanostar uniformly dispersed in the surface of the microrobot?

2.     As shown in Figure1, the microrobot was located in the blood vessel not in tumor. So the pH value of this environment is not 5.0. The design of drug release is not reasonable.

3.     How can the microrobot reach the tumor sites?

4.     The application of the microrobot for tumor therapy should be rationally designed.

Author Response

Thank you so much for the reviewer's valuable comments.
Attached, please find the responses to the reviewer.

Thank you.

 

Author Response File: Author Response.pdf

Reviewer 2 Report

Nice workl!

Author Response

Thank you so much for the kind review.

Round 2

Reviewer 1 Report

Accept

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