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Review

Selinexor and the Selective Inhibition of Nuclear Export: A New Perspective on the Treatment of Sarcomas and Other Solid and Non-Solid Tumors

by
Antonella Lucia Marretta
1,
Giuseppe Di Lorenzo
2,
Dario Ribera
1,*,
Lucia Cannella
2,
Claudia von Arx
3,
Alessandra Bracigliano
4,
Ottavia Clemente
2,
Roberto Tafuto
5,
Antonio Pizzolorusso
2 and
Salvatore Tafuto
2
1
Department of Clinical and Surgery Oncology Unit, University of Naples “Federico II”, Via S. Pansini 5, 80131 Naples, Italy
2
Sarcomas and Rare Tumors Unit, Istituto Nazionale Tumori—IRCCS, Fondazione “G. Pascale”, 80131 Naples, Italy
3
Department of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto Nazionale Tumori—IRCCS, Fondazione “G. Pascale”, 80131 Naples, Italy
4
Nuclear Medicine Unit, Istituto Nazionale Tumori—IRCCS, Fondazione “G. Pascale”, Via M. Semmola 53, 80131 Naples, Italy
5
Division of Neurosurgery, University of Naples “Federico II”, Via S. Pansini 5, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
Pharmaceutics 2021, 13(9), 1522; https://doi.org/10.3390/pharmaceutics13091522
Submission received: 6 July 2021 / Revised: 15 September 2021 / Accepted: 16 September 2021 / Published: 20 September 2021

Abstract

Nucleocytoplasmic transport has been found dysregulated in many types of cancer and is often described as a poor prognostic factor. Specifically, Exportin-1 (XPO1) has been found overexpressed in many tumors and has become an attractive target in molecular oncology and therapeutics development. The selective inhibitor of nuclear export, Selinexor, is one of the most scientifically interesting drugs that targets XPO1 in clinical development. In this review, we summarized the most relevant preclinical and clinical results achieved for non-solid tumors, sarcomas, and other kind of solid tumors.
Keywords: selinexor; XPO1; SINE; soft tissue sarcoma; metastatic cancer; multiple myeloma; leukemia; gynecologic cancer; target therapy selinexor; XPO1; SINE; soft tissue sarcoma; metastatic cancer; multiple myeloma; leukemia; gynecologic cancer; target therapy
Graphical Abstract

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MDPI and ACS Style

Marretta, A.L.; Di Lorenzo, G.; Ribera, D.; Cannella, L.; von Arx, C.; Bracigliano, A.; Clemente, O.; Tafuto, R.; Pizzolorusso, A.; Tafuto, S. Selinexor and the Selective Inhibition of Nuclear Export: A New Perspective on the Treatment of Sarcomas and Other Solid and Non-Solid Tumors. Pharmaceutics 2021, 13, 1522. https://doi.org/10.3390/pharmaceutics13091522

AMA Style

Marretta AL, Di Lorenzo G, Ribera D, Cannella L, von Arx C, Bracigliano A, Clemente O, Tafuto R, Pizzolorusso A, Tafuto S. Selinexor and the Selective Inhibition of Nuclear Export: A New Perspective on the Treatment of Sarcomas and Other Solid and Non-Solid Tumors. Pharmaceutics. 2021; 13(9):1522. https://doi.org/10.3390/pharmaceutics13091522

Chicago/Turabian Style

Marretta, Antonella Lucia, Giuseppe Di Lorenzo, Dario Ribera, Lucia Cannella, Claudia von Arx, Alessandra Bracigliano, Ottavia Clemente, Roberto Tafuto, Antonio Pizzolorusso, and Salvatore Tafuto. 2021. "Selinexor and the Selective Inhibition of Nuclear Export: A New Perspective on the Treatment of Sarcomas and Other Solid and Non-Solid Tumors" Pharmaceutics 13, no. 9: 1522. https://doi.org/10.3390/pharmaceutics13091522

APA Style

Marretta, A. L., Di Lorenzo, G., Ribera, D., Cannella, L., von Arx, C., Bracigliano, A., Clemente, O., Tafuto, R., Pizzolorusso, A., & Tafuto, S. (2021). Selinexor and the Selective Inhibition of Nuclear Export: A New Perspective on the Treatment of Sarcomas and Other Solid and Non-Solid Tumors. Pharmaceutics, 13(9), 1522. https://doi.org/10.3390/pharmaceutics13091522

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