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Article

Drug-Loaded Hydrogels for Intraocular Lenses with Prophylactic Action against Pseudophakic Cystoid Macular Edema

1
Centro de Química Estrutural, Instituto Superior Técnico, University of Lisbon, Avenue Rovisco Pais, 1049-001 Lisbon, Portugal
2
Centro de Investigação Interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal
3
HGBeyond Materials Science S.L., Edificio EMPRENDIA, 15782 Santiago de Compostela, Spain
4
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I + D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Laurence Fitzhenry and Rocio Herrero-Vanrell
Pharmaceutics 2021, 13(7), 976; https://doi.org/10.3390/pharmaceutics13070976
Received: 7 June 2021 / Revised: 23 June 2021 / Accepted: 24 June 2021 / Published: 28 June 2021
(This article belongs to the Special Issue Innovative Technologies to Treat Diseases of the Back of the Eye)
Pseudophakic cystoid macular edema (PCME), caused by chronic inflammation, is the most common cause of visual impairment in the medium-term after cataract surgery. Therefore, the prophylactic topical administration of combined steroidal and non-steroidal anti-inflammatory drugs is commonly done. Drug-eluting intraocular lenses (IOLs) gained interest as an efficient way to overcome the compliance issues related to the use of ocular drops without the need for additional surgical steps. The incorporation of functional monomers and molecular imprinting were herein applied to design hydrogels suitable as IOLs and able to co-deliver steroidal (dexamethasone sodium phosphate) and non-steroidal (bromfenac sodium) drugs. The incorporation of N-(2-aminopropyl) methacrylamide (APMA) increased the drug uptake and improved the in vitro release kinetics. Imprinting with bromfenac resulted in a decreased drug release due to permanent drug bonding, while imprinting with dexamethasone increased the amount of dexamethasone released after dual-drug loading. The application of a mathematical model to predict the in vivo drug release behavior suggests the feasibility of achieving therapeutic drug concentrations of bromfenac and dexamethasone in the aqueous humor for about 2 and 8 weeks, respectively, which is compatible with the current topical prophylaxis after cataract surgery. View Full-Text
Keywords: therapeutic ophthalmic lenses; posterior segment diseases; drug release; anti-inflammatory drug; molecular imprinting; functionalized hydrogels therapeutic ophthalmic lenses; posterior segment diseases; drug release; anti-inflammatory drug; molecular imprinting; functionalized hydrogels
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MDPI and ACS Style

Toffoletto, N.; Salema-Oom, M.; Anguiano Igea, S.; Alvarez-Lorenzo, C.; Saramago, B.; Serro, A.P. Drug-Loaded Hydrogels for Intraocular Lenses with Prophylactic Action against Pseudophakic Cystoid Macular Edema. Pharmaceutics 2021, 13, 976. https://doi.org/10.3390/pharmaceutics13070976

AMA Style

Toffoletto N, Salema-Oom M, Anguiano Igea S, Alvarez-Lorenzo C, Saramago B, Serro AP. Drug-Loaded Hydrogels for Intraocular Lenses with Prophylactic Action against Pseudophakic Cystoid Macular Edema. Pharmaceutics. 2021; 13(7):976. https://doi.org/10.3390/pharmaceutics13070976

Chicago/Turabian Style

Toffoletto, Nadia, Madalena Salema-Oom, Soledad Anguiano Igea, Carmen Alvarez-Lorenzo, Benilde Saramago, and Ana P. Serro. 2021. "Drug-Loaded Hydrogels for Intraocular Lenses with Prophylactic Action against Pseudophakic Cystoid Macular Edema" Pharmaceutics 13, no. 7: 976. https://doi.org/10.3390/pharmaceutics13070976

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