An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine
Abstract
:1. Introduction
2. MSN Synthesis and Classification
3. The Fundamentals of MSN-Based Drug Delivery
3.1. Functionalization
3.2. Drug Loading
3.3. Drug Delivery
3.4. Drug Release
4. Update on MSN Applications in Nanomedicines
4.1. The Application of MSNs in Tissue Engineering
4.1.1. MSN Application in Bone Tissue Engineering
4.1.2. MSN Application in Vascular Tissue Engineering
4.1.3. MSN Application in Wound Healing and Antibacterial Effects
4.2. MSN Applications in Bioimaging
4.2.1. MSN Application in Optical Imaging
4.2.2. MSN Applications in Magnetic Resonance Imaging and Positron Emission Tomography
4.2.3. MSN Application in Multi-Modal Imaging
4.3. MSN Application in Stem Cell Research
4.3.1. MSN Application in Stem Cell Maintenance and Differentiation
4.3.2. MSN Application in Cancer Stem Cell Ablation
4.3.3. MSN Application in Stem Cell Labeling
4.4. MSN Application in Anti-Cancer/Tumor Therapy
4.4.1. MSN Applications in Photodynamic Therapy (PDT) and Sonodynamic Therapy (SDT)
4.4.2. MSN Application in Chemotherapy
4.4.3. MSN Application in Radiation Therapy
4.4.4. MSN Application in Gene Therapy
4.4.5. MSN Application in Immunotherapy
5. Biocompatibility and Safety of MSNs
6. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Section | Updated MSN Applications in Nanomedicines | Page |
---|---|---|
4.1 | Tissue engineering | 12 |
4.1.1. | —bone tissue engineering | 12 |
4.1.2. | —vascular tissue engineering | 14 |
4.1.3. | —wound healing and antibacterial effects | 15 |
4.2 | Bioimaging | 17 |
4.2.1. | —optical imaging | 18 |
4.2.2. | —magnetic resonance imaging and positron emission tomography | 19 |
4.2.3. | —multi-modal imaging | 20 |
4.3 | Stem cell research | 22 |
4.3.1. | —stem cell maintenance and differentiation | 22 |
4.3.2. | —cancer stem cell ablation | 24 |
4.3.3. | —stem cell labeling | 27 |
4.4 | Anti-cancer/tumor therapy | 27 |
4.4.1. | —photodynamic and sonodynamic therapies | 28 |
4.4.2. | —chemotherapy | 32 |
4.4.3. | —radiation therapy | 33 |
4.4.4. | —gene therapy | 35 |
4.4.5. | —immunotherapy | 35 |
Classifications of MSNs | |||
---|---|---|---|
Traditional MSNs | Reference | ||
Mobil Crystalline Material (MCM) | Mobil Oil Corporation | MCM-41, MCM-49, MCM-50 | [74,75,76,77,78,79] |
Santa Barbara Amorphous (SBA) | University of California at Santa Barbara | SBA-12, SBA-15, SBA-16 | [69,70,80,81] |
Korea Institute of Technology (KIT) | Korea Advanced Institute of Science and Technology | KIT-5, KIT-6 | [82,83] |
Centrum voor Oppervlaktechemie en Katalyse (COK) | Centre for Research Chemistry and Catalysis | COK-12 | [84] |
Modern MSNs | |||
Hollow MSNs | - | HMSNs | [73,85,86,87,88,89,90] |
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Rastegari, E.; Hsiao, Y.-J.; Lai, W.-Y.; Lai, Y.-H.; Yang, T.-C.; Chen, S.-J.; Huang, P.-I.; Chiou, S.-H.; Mou, C.-Y.; Chien, Y. An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine. Pharmaceutics 2021, 13, 1067. https://doi.org/10.3390/pharmaceutics13071067
Rastegari E, Hsiao Y-J, Lai W-Y, Lai Y-H, Yang T-C, Chen S-J, Huang P-I, Chiou S-H, Mou C-Y, Chien Y. An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine. Pharmaceutics. 2021; 13(7):1067. https://doi.org/10.3390/pharmaceutics13071067
Chicago/Turabian StyleRastegari, Elham, Yu-Jer Hsiao, Wei-Yi Lai, Yun-Hsien Lai, Tien-Chun Yang, Shih-Jen Chen, Pin-I Huang, Shih-Hwa Chiou, Chung-Yuan Mou, and Yueh Chien. 2021. "An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine" Pharmaceutics 13, no. 7: 1067. https://doi.org/10.3390/pharmaceutics13071067
APA StyleRastegari, E., Hsiao, Y.-J., Lai, W.-Y., Lai, Y.-H., Yang, T.-C., Chen, S.-J., Huang, P.-I., Chiou, S.-H., Mou, C.-Y., & Chien, Y. (2021). An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine. Pharmaceutics, 13(7), 1067. https://doi.org/10.3390/pharmaceutics13071067