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Article

Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution

1
Institute of Chemical Process Fundamentals of CAS v.v.i., Rozvojová 135, 16502 Prague, Czech Republic
2
Department of Analytical Chemistry, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic
3
Forensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 16628 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Anne Marie Healy
Pharmaceutics 2021, 13(3), 412; https://doi.org/10.3390/pharmaceutics13030412
Received: 2 February 2021 / Revised: 5 March 2021 / Accepted: 16 March 2021 / Published: 19 March 2021
Stability studies represent an essential component of pharmaceutical development, enabling critical evaluation of the therapeutic potential of an active pharmaceutical ingredient (API) or a final pharmaceutical product under the influence of various environmental factors. The aim of the present study was to investigate the chemical stability of cannabidiol (CBD) in the form of a solid powder (hereinafter referred to as CBD powder) and also dissolved in sunflower oil. We performed stress studies in accordance with the International Conference on Harmonization (ICH) guidelines, where 5 mg of marketed CBD in the form of a solid powder and in form of oil solution were exposed for 7 and 14, 30, 60, 90, 180, 270, and 365 days to precisely defined temperature and humidity conditions, 25 °C ± 2 °C/60% RH ± 5% and 40 °C ± 2 °C/75% RH ± 5% in both open and closed vials in the dark. CBD powder was significantly more stable than CBD in oil solution. Such finding is important because CBD is often administered dissolved in oil matrix in practice due to very good bioavailability. Thus, the knowledge on admissible shelf time is of paramount importance. View Full-Text
Keywords: cannabidiol; degradation; oil matrix; stability study; tetrahydrocannabinol; cannabinol cannabidiol; degradation; oil matrix; stability study; tetrahydrocannabinol; cannabinol
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MDPI and ACS Style

Kosović, E.; Sýkora, D.; Kuchař, M. Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution. Pharmaceutics 2021, 13, 412. https://doi.org/10.3390/pharmaceutics13030412

AMA Style

Kosović E, Sýkora D, Kuchař M. Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution. Pharmaceutics. 2021; 13(3):412. https://doi.org/10.3390/pharmaceutics13030412

Chicago/Turabian Style

Kosović, Ema, David Sýkora, and Martin Kuchař. 2021. "Stability Study of Cannabidiol in the Form of Solid Powder and Sunflower Oil Solution" Pharmaceutics 13, no. 3: 412. https://doi.org/10.3390/pharmaceutics13030412

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