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Article

Nanoencapsulation of Pomegranate Extract to Increase Stability and Potential Dermatological Protection

1
Aquaporins Group, Centro de Edafología y Biología Aplicada del Segura (CEBAS-CSIC), Campus de Espinardo, E-30100 Murcia, Spain
2
Biotechnology of Fruit Trees Group, Centro de Edafología y Biología Aplicada del Segura (CEBAS-CSIC), Campus de Espinardo, E-30100 Murcia, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Maria Camilla Bergonzi
Pharmaceutics 2021, 13(2), 271; https://doi.org/10.3390/pharmaceutics13020271
Received: 16 December 2020 / Revised: 28 January 2021 / Accepted: 10 February 2021 / Published: 17 February 2021
(This article belongs to the Special Issue Liposomal Drug Delivery Systems)
Pomegranate extract (PG-E) has been reported to exert a protective effect on the skin due to its antioxidant activity. Ingredients rich in phenolic compounds are unstable in extract solutions, and, therefore, the use of a suitable nanosystem to encapsulate this type of extract could be necessary in different biotechnological applications. Thus, we investigated the capacity of Brassica oleracea L. (cauliflower) inflorescence vesicles (CI-vesicles) to encapsulate PG-E and determined the stability and the antioxidant capacity of the system over time. In addition, the protective effect against UV radiation and heavy metals in HaCaT cells was also tested. The CI-vesicles had an entrapment efficiency of around 50%, and accelerated stability tests did not show significant changes in the parameters tested. The results for the HaCaT cells showed the non-cytotoxicity of the CI-vesicles containing PG-E and their protection against heavy metals (lead acetate and mercuric chloride) and UV-B radiation through a reduction of oxidative stress. The reduction of the percentage of deleted mtDNA (mtDNA4977, “common deletion”) in UV-treated HaCaT cells due to the presence of CI-vesicles containing PG-E indicated the mechanism of protection. Therefore, the effects of CI-vesicles loaded with PG-E against oxidative stress support their utilization as natural cosmeceuticals to protect skin health against external damage from environmental pollution and UV radiation. View Full-Text
Keywords: pomegranate; antioxidant capacity; membrane vesicles; cauliflower; keratinocytes; oxidative stress; cytotoxicity pomegranate; antioxidant capacity; membrane vesicles; cauliflower; keratinocytes; oxidative stress; cytotoxicity
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MDPI and ACS Style

Yepes-Molina, L.; Hernández, J.A.; Carvajal, M. Nanoencapsulation of Pomegranate Extract to Increase Stability and Potential Dermatological Protection. Pharmaceutics 2021, 13, 271. https://doi.org/10.3390/pharmaceutics13020271

AMA Style

Yepes-Molina L, Hernández JA, Carvajal M. Nanoencapsulation of Pomegranate Extract to Increase Stability and Potential Dermatological Protection. Pharmaceutics. 2021; 13(2):271. https://doi.org/10.3390/pharmaceutics13020271

Chicago/Turabian Style

Yepes-Molina, Lucía, José A. Hernández, and Micaela Carvajal. 2021. "Nanoencapsulation of Pomegranate Extract to Increase Stability and Potential Dermatological Protection" Pharmaceutics 13, no. 2: 271. https://doi.org/10.3390/pharmaceutics13020271

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