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Open AccessArticle

Selective Laser Sintering of Solid Oral Dosage Forms with Copovidone and Paracetamol Using a CO2 Laser

1
ICGM, University Montpellier, CNRS, ENSCM, 34000 Montpellier, France
2
IBMM, University Montpellier, CNRS, ENSCM, 34000 Montpellier, France
3
Department of Pharmacy, Nîmes University Hospital, 30900 Nimes, France
*
Author to whom correspondence should be addressed.
Pharmaceutics 2021, 13(2), 160; https://doi.org/10.3390/pharmaceutics13020160
Received: 4 December 2020 / Revised: 21 January 2021 / Accepted: 22 January 2021 / Published: 26 January 2021
(This article belongs to the Section Pharmaceutical Technology, Manufacturing and Devices)
Material suitability needs to be considered for the 3D printing of solid oral dosage forms (SODFs). This work aims to assess the suitability of a CO2 laser (λ = 10.6 μm) for selective laser sintering of SODFs containing copovidone and paracetamol. First, physicochemical characterization of powders (two grades of copovidone, two grades of paracetamol and their mixtures at various proportions) was conducted: particle size distribution, morphology, infrared absorbance, flowability, and compactness. Then, printing was launched, and printability of the powders was linked to their physicochemical characteristics. The properties of the sintered SODFs were evaluated (solid state, general aspect, porosity, hardness, drug content and release). Hence, it was found that as copovidone absorbs at the laser’s wavelength, sintering was feasible without using an absorbance enhancer. Also, flowability, which mainly depends on the particle size, represents the first control line for “sinterability” as a fair flow is at least required. Low compactness of copovidone and mixtures reduces the mechanical properties of the SODFs but also increases porosity, which can modulate drug release. Moreover, the drug did not undergo degradation and demonstrated a plasticizer effect by lowering the heating temperature. In conclusion, this work proves the applicability of CO2 laser SLS printer to produce SODFs. View Full-Text
Keywords: 3D printing; selective laser sintering; copovidone; oral dosage forms; material suitability; printability 3D printing; selective laser sintering; copovidone; oral dosage forms; material suitability; printability
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MDPI and ACS Style

Gueche, Y.A.; Sanchez-Ballester, N.M.; Bataille, B.; Aubert, A.; Leclercq, L.; Rossi, J.-C.; Soulairol, I. Selective Laser Sintering of Solid Oral Dosage Forms with Copovidone and Paracetamol Using a CO2 Laser. Pharmaceutics 2021, 13, 160. https://doi.org/10.3390/pharmaceutics13020160

AMA Style

Gueche YA, Sanchez-Ballester NM, Bataille B, Aubert A, Leclercq L, Rossi J-C, Soulairol I. Selective Laser Sintering of Solid Oral Dosage Forms with Copovidone and Paracetamol Using a CO2 Laser. Pharmaceutics. 2021; 13(2):160. https://doi.org/10.3390/pharmaceutics13020160

Chicago/Turabian Style

Gueche, Yanis A.; Sanchez-Ballester, Noelia M.; Bataille, Bernard; Aubert, Adrien; Leclercq, Laurent; Rossi, Jean-Christophe; Soulairol, Ian. 2021. "Selective Laser Sintering of Solid Oral Dosage Forms with Copovidone and Paracetamol Using a CO2 Laser" Pharmaceutics 13, no. 2: 160. https://doi.org/10.3390/pharmaceutics13020160

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