Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases
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Department of Internal Medicine, Tainan Hospital, Ministry of Health and Welfare, Tainan 70007, Taiwan
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Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan
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Department of Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
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Master of Biomedicine Program, National Taitung University, Taitung 95092, Taiwan
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Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan
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Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
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Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan 70101, Taiwan
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Department of Pathology, National Cheng Kung University Hospital, Tainan 70101, Taiwan
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Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK 74107, USA
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Authors to whom correspondence should be addressed.
Academic Editors: Teresa Cerchiara and Maria Nowakowska
Pharmaceutics 2021, 13(11), 1913; https://doi.org/10.3390/pharmaceutics13111913
Received: 1 October 2021
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Revised: 8 November 2021
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Accepted: 10 November 2021
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Published: 12 November 2021
(This article belongs to the Special Issue Nanomaterials and Novel Biologics to Manage Bacterial Infections)
Bacteria-targeting nanomaterials have been widely used in the diagnosis and treatment of bacterial infectious diseases. These nanomaterials show great potential as antimicrobial agents due to their broad-spectrum antibacterial capacity and relatively low toxicity. Recently, nanomaterials have improved the accurate detection of pathogens, provided therapeutic strategies against nosocomial infections and facilitated the delivery of antigenic protein vaccines that induce humoral and cellular immunity. Biomaterial implants, which have traditionally been hindered by bacterial colonization, benefit from their ability to prevent bacteria from forming biofilms and spreading into adjacent tissues. Wound repair is improving in terms of both the function and prevention of bacterial infection, as we tailor nanomaterials to their needs, select encapsulation methods and materials, incorporate activation systems and add immune-activating adjuvants. Recent years have produced numerous advances in their antibacterial applications, but even further expansion in the diagnosis and treatment of infectious diseases is expected in the future.
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Keywords:
nanoparticle; silver nanoparticle; biofilms; implants; bacterial infection; polymers
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MDPI and ACS Style
Hung, Y.-P.; Chen, Y.-F.; Tsai, P.-J.; Huang, I.-H.; Ko, W.-C.; Jan, J.-S. Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases. Pharmaceutics 2021, 13, 1913. https://doi.org/10.3390/pharmaceutics13111913
AMA Style
Hung Y-P, Chen Y-F, Tsai P-J, Huang I-H, Ko W-C, Jan J-S. Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases. Pharmaceutics. 2021; 13(11):1913. https://doi.org/10.3390/pharmaceutics13111913
Chicago/Turabian StyleHung, Yuan-Pin, Yu-Fon Chen, Pei-Jane Tsai, I-Hsiu Huang, Wen-Chien Ko, and Jeng-Shiung Jan. 2021. "Advances in the Application of Nanomaterials as Treatments for Bacterial Infectious Diseases" Pharmaceutics 13, no. 11: 1913. https://doi.org/10.3390/pharmaceutics13111913
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