Tumor-Targeted ZW800-1 Analog for Enhanced Tumor Imaging and Photothermal Therapy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Synthesis of Zwitterionic NIR Fluorophores
2.2. Optical and Physicochemical Property Analyses
2.3. In Vitro Cell Binding and NIR Fluorescence Microscopy
2.4. In Vitro Cytotoxicity Assay
2.5. NCI-H460 Xenograft Mouse Model
2.6. In Vivo Biodistribution and Tumor Imaging
2.7. In Vivo Photothermal Therapeutic Efficacy
2.8. Statistical Analysis
2.9. Histological Analysis
3. Results and Discussion
3.1. Synthesis and Characterization of ZW800-AM
3.2. In Vitro Cancer Cell Binding and Cytotoxicity
3.3. Time-Dependent In Vivo Tumor Imaging and Biodistribution
3.4. In Vitro and In Vivo Photothermal Effects
3.5. In Vivo Photothermal Therapeutic Efficacy
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Park, M.-H.; Jo, G.; Kim, E.-J.; Hyun, H. Tumor-Targeted ZW800-1 Analog for Enhanced Tumor Imaging and Photothermal Therapy. Pharmaceutics 2021, 13, 1648. https://doi.org/10.3390/pharmaceutics13101648
Park M-H, Jo G, Kim E-J, Hyun H. Tumor-Targeted ZW800-1 Analog for Enhanced Tumor Imaging and Photothermal Therapy. Pharmaceutics. 2021; 13(10):1648. https://doi.org/10.3390/pharmaceutics13101648
Chicago/Turabian StylePark, Min-Ho, Gayoung Jo, Eun-Jeong Kim, and Hoon Hyun. 2021. "Tumor-Targeted ZW800-1 Analog for Enhanced Tumor Imaging and Photothermal Therapy" Pharmaceutics 13, no. 10: 1648. https://doi.org/10.3390/pharmaceutics13101648
APA StylePark, M.-H., Jo, G., Kim, E.-J., & Hyun, H. (2021). Tumor-Targeted ZW800-1 Analog for Enhanced Tumor Imaging and Photothermal Therapy. Pharmaceutics, 13(10), 1648. https://doi.org/10.3390/pharmaceutics13101648