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Hyaluronan/Poly-L-lysine/Berberine Nanogels for Impaired Wound Healing

Department of Drug Sciences, University of Catania; V.le Andrea Doria, 6, 95125 Catania, Italy
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
Authors to whom correspondence should be addressed.
Pharmaceutics 2021, 13(1), 34;
Received: 31 October 2020 / Revised: 15 December 2020 / Accepted: 22 December 2020 / Published: 28 December 2020
(This article belongs to the Special Issue Natural Products in Drug Delivery Systems)
Physiological wound healing process can be delayed in the presence of certain pathologies, such as diabetes or cancer. In this perspective, the aim of this study was to design a new nanogel platform of hyaluronan, poly-L-lysine and berberine suitable for wound treatment. Two different nanogel formulations were selected after a first formulation screening. They were prepared by adding dropwise 2 mg/mL hyaluronan aqueous solution (200 or 700 kDa) to 1.25 mg/mL poly-L-lysine aqueous solution. Blank nanogels formulated with 200 kDa HA resulted stable after freeze-drying with dimensions, polydispersity index and zeta potential of 263.6 ± 13.1 nm, 0.323 ± 0.029 and 32.7 ± 3.5 mV, respectively. Both blank and berberine-loaded nanogels showed rounded-shape structures. Loaded nanogels released nearly 50% of loaded berberine within 45 min, whereas the remaining 50% was released up to 24 h in vitro. Both, blank and berberine-loaded nanogels were able to completely close the fibroblasts gap in 42 h. View Full-Text
Keywords: hyaluronan; ε-polylysine; berberine; chronic wounds; nanogels hyaluronan; ε-polylysine; berberine; chronic wounds; nanogels
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MDPI and ACS Style

Amato, G.; Grimaudo, M.A.; Alvarez-Lorenzo, C.; Concheiro, A.; Carbone, C.; Bonaccorso, A.; Puglisi, G.; Musumeci, T. Hyaluronan/Poly-L-lysine/Berberine Nanogels for Impaired Wound Healing. Pharmaceutics 2021, 13, 34.

AMA Style

Amato G, Grimaudo MA, Alvarez-Lorenzo C, Concheiro A, Carbone C, Bonaccorso A, Puglisi G, Musumeci T. Hyaluronan/Poly-L-lysine/Berberine Nanogels for Impaired Wound Healing. Pharmaceutics. 2021; 13(1):34.

Chicago/Turabian Style

Amato, Giovanni, Maria A. Grimaudo, Carmen Alvarez-Lorenzo, Angel Concheiro, Claudia Carbone, Angela Bonaccorso, Giovanni Puglisi, and Teresa Musumeci. 2021. "Hyaluronan/Poly-L-lysine/Berberine Nanogels for Impaired Wound Healing" Pharmaceutics 13, no. 1: 34.

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