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Article

Design and Characterization of Elastic Artificial Skin Containing Adenosine-Loaded Solid Lipid Nanoparticles for Treating Wrinkles

1
College of Pharmacy, Chung-Ang University, Seoul 06974, Korea
2
R&D Center, Megacos, 16, Simin-daero 327 Rd, Dongan-gu, Anyang-si, Gyeonggi-do 14055, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Pharmaceutics 2021, 13(1), 33; https://doi.org/10.3390/pharmaceutics13010033
Received: 25 November 2020 / Revised: 22 December 2020 / Accepted: 25 December 2020 / Published: 28 December 2020
(This article belongs to the Special Issue Skin and Formulation)
Adenosine (AD), which is used for treating wrinkles, exhibits poor skin permeation. The aim of the present study was to develop a cross-linked silicone-based cellulose elastomer as an elastic artificial skin for the treatment of skin wrinkles, a biocompatible lipid-based nano-carrier for enhancing the skin permeation of AD, and a formulation consisting of the lipid-based carrier incorporated in the elastic artificial skin. AD-loaded solid lipid nanoparticles (SLNs) were prepared using a double-emulsion method. Particle characteristics and mechanical properties of SLNs and elastic artificial skin, respectively, were assessed. Skin permeation was evaluated using SkinEthic RHE tissue, a reconstructed human epidermis model. The mean particle size and zeta potential for SLNs ranged from 123.57 to 248.90 nm and −13.23 to −41.23 mV, respectively. The components of neither SLNs nor the elastic artificial skin were cytotoxic, according to cell- and tissue-viability assays and EU classification. SLNs and the elastic artificial skin exhibited sustained drug release for 48 h. The amount of AD released from SLNs and elastic artificial skin was approximately 10 times and 5 times higher, respectively, than that from AD solution. Therefore, elastic artificial skin incorporated with AD-loaded SLNs may serve as a promising topical delivery system for cosmeceutical treatment of skin wrinkles. View Full-Text
Keywords: adenosine; solid lipid nanoparticles; elastic artificial skin; anti-wrinkle; skin permeation adenosine; solid lipid nanoparticles; elastic artificial skin; anti-wrinkle; skin permeation
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MDPI and ACS Style

Yeo, S.; Jung, S.; Cho, H.K.; Kim, Y.H.; Kim, G.H.; Kim, D.; Ko, B.H.; Lee, J. Design and Characterization of Elastic Artificial Skin Containing Adenosine-Loaded Solid Lipid Nanoparticles for Treating Wrinkles. Pharmaceutics 2021, 13, 33. https://doi.org/10.3390/pharmaceutics13010033

AMA Style

Yeo S, Jung S, Cho HK, Kim YH, Kim GH, Kim D, Ko BH, Lee J. Design and Characterization of Elastic Artificial Skin Containing Adenosine-Loaded Solid Lipid Nanoparticles for Treating Wrinkles. Pharmaceutics. 2021; 13(1):33. https://doi.org/10.3390/pharmaceutics13010033

Chicago/Turabian Style

Yeo, Sooho, Sukkyun Jung, Heui Kyoung Cho, Young Ho Kim, Gi Hwan Kim, Dohyun Kim, Byoung Hyen Ko, and Jaehwi Lee. 2021. "Design and Characterization of Elastic Artificial Skin Containing Adenosine-Loaded Solid Lipid Nanoparticles for Treating Wrinkles" Pharmaceutics 13, no. 1: 33. https://doi.org/10.3390/pharmaceutics13010033

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