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Article

Medicines Acceptability in Hospitalized Children: An Ongoing Need for Age-Appropriate Formulations

1
ClinSearch, 110 Avenue Pierre Brossolette, 92240 Malakoff, France
2
Faculty of Pharmacy and Medicine, Mohammed V University in Rabat, Impasse Souissi, 10170 Rabat, Morocco
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Specialties Hospital, University Medical Centre Ibn Sina (CHIS), Quartier Souissi, 10170 Rabat, Morocco
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Pediatrics Hospital, University Medical Centre Ibn Sina (CHIS), Avenue Ibn Rochd, 10100 Rabat, Morocco
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EBInnov, Ecole de Biologie Industrielle (EBI), 49 Avenue des Genottes, 95800 Cergy-Pontoise, France
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(8), 766; https://doi.org/10.3390/pharmaceutics12080766
Received: 30 June 2020 / Revised: 31 July 2020 / Accepted: 10 August 2020 / Published: 13 August 2020
(This article belongs to the Special Issue Paediatric Drug Delivery)
Although knowledge on medicine acceptability remains fragmented, this multi-faceted concept has emerged as a key factor for compliance in pediatrics. In order to investigate the acceptability of medicines used in the University Medical Centre Ibn Sina (CHIS) of Rabat, Morocco, an observational study was conducted. Using a multivariate approach integrating the many aspects of acceptability, standardized observer reports were collected for 570 medicine intakes in patients up to the age of 16, then analyzed on a reference framework. Tablets appeared to be well accepted in children greater than 6 years old, but were crushed/dissolved for 90% of the 40 children aged from 3 to 5, and 100% of the 38 patients younger than 3. Moreover, the prescribed dose was fully taken for only 52% and 16% of these younger children, respectively. Despite this, tablets represented 24% of evaluations in children from 3 to 5 and 20% in infants and toddlers. Oral liquid preparations appeared to be better accepted than tablets in preschoolers, but not for those under 3. Overall, these findings highlight the lack of suitable alternatives for the younger children, especially for formulations of antiepileptics, antithrombotic, and psycholeptic agents in the local context.
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Keywords: medicine; acceptability; swallowability; tablet; pediatric; children; formulation; hospital; clinsearch acceptability score test (CAST) medicine; acceptability; swallowability; tablet; pediatric; children; formulation; hospital; clinsearch acceptability score test (CAST)
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MDPI and ACS Style

Vallet, T.; Elhamdaoui, O.; Berraho, A.; Cherkaoui, L.O.; Kriouile, Y.; Mahraoui, C.; Mouane, N.; Pense-Lheritier, A.-M.; Ruiz, F.; Bensouda, Y. Medicines Acceptability in Hospitalized Children: An Ongoing Need for Age-Appropriate Formulations. Pharmaceutics 2020, 12, 766. https://doi.org/10.3390/pharmaceutics12080766

AMA Style

Vallet T, Elhamdaoui O, Berraho A, Cherkaoui LO, Kriouile Y, Mahraoui C, Mouane N, Pense-Lheritier A-M, Ruiz F, Bensouda Y. Medicines Acceptability in Hospitalized Children: An Ongoing Need for Age-Appropriate Formulations. Pharmaceutics. 2020; 12(8):766. https://doi.org/10.3390/pharmaceutics12080766

Chicago/Turabian Style

Vallet, Thibault, Omar Elhamdaoui, Amina Berraho, Lalla O. Cherkaoui, Yamna Kriouile, Chafiq Mahraoui, Nezha Mouane, Anne-Marie Pense-Lheritier, Fabrice Ruiz, and Yahya Bensouda. 2020. "Medicines Acceptability in Hospitalized Children: An Ongoing Need for Age-Appropriate Formulations" Pharmaceutics 12, no. 8: 766. https://doi.org/10.3390/pharmaceutics12080766

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