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Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art

1
Department of Pharmaceutics, Faculty of Pharmacy, University of Bonn, 53121 Bonn, Germany
2
Department of Neurosurgery, University Clinic of Bonn, 53105 Bonn, Germany
3
PEPITE EA4267, Institute of Pharmacy, University Bourgogne Franche-Comté, 25000 Besançon, France
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(6), 510; https://doi.org/10.3390/pharmaceutics12060510
Received: 29 April 2020 / Accepted: 24 May 2020 / Published: 3 June 2020
(This article belongs to the Section Nanomedicine and Nanotechnology)
Within recent decades, the development of nanotechnology has made a significant contribution to the progress of various fields of study, including the domains of medical and pharmaceutical sciences. A substantially transformed arena within the context of the latter is the development and production of various injectable parenteral formulations. Indeed, recent decades have witnessed a rapid growth of the marketed and pipeline nanotechnology-based injectable products, which is a testimony to the remarkability of the aforementioned contribution. Adjunct to the ability of nanomaterials to deliver the incorporated payloads to many different targets of interest, nanotechnology has substantially assisted to the development of many further facets of the art. Such contributions include the enhancement of the drug solubility, development of long-acting locally and systemically injectable formulations, tuning the onset of the drug’s release through the endowment of sensitivity to various internal or external stimuli, as well as adjuvancy and immune activation, which is a desirable component for injectable vaccines and immunotherapeutic formulations. The current work seeks to provide a comprehensive review of all the abovementioned contributions, along with the most recent advances made within each domain. Furthermore, recent developments within the domains of passive and active targeting will be briefly debated. View Full-Text
Keywords: nanotechnology; injectable parenteral formulations; solubility enhancement; controlled release; targeting; adjuvancy; immune activation nanotechnology; injectable parenteral formulations; solubility enhancement; controlled release; targeting; adjuvancy; immune activation
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MDPI and ACS Style

Shetab Boushehri, M.A.; Dietrich, D.; Lamprecht, A. Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art. Pharmaceutics 2020, 12, 510. https://doi.org/10.3390/pharmaceutics12060510

AMA Style

Shetab Boushehri MA, Dietrich D, Lamprecht A. Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art. Pharmaceutics. 2020; 12(6):510. https://doi.org/10.3390/pharmaceutics12060510

Chicago/Turabian Style

Shetab Boushehri, Maryam A.; Dietrich, Dirk; Lamprecht, Alf. 2020. "Nanotechnology as a Platform for the Development of Injectable Parenteral Formulations: A Comprehensive Review of the Know-Hows and State of the Art" Pharmaceutics 12, no. 6: 510. https://doi.org/10.3390/pharmaceutics12060510

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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