Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review
Abstract
:1. Introduction
2. The Anatomy of the Cornea
3. Methods for Cornea Drug Delivery
3.1. Topical Methods
3.1.1. Liquid/Solution Eye Drops
3.1.2. Ointments
3.1.3. Ocular Gel
3.2. Drug Loaded Ocular Inserts
3.2.1. Contact Lenses
3.2.2. Punctal Plugs
3.3. Injection
4. Nanostructured Materials and Properties
5. Nanoparticles as Biodegradable Nanocarriers for Cornea Drug Delivery
5.1. Liposomes
Kinds of Drug | Result |
---|---|
Acyclovir loaded liposome for herpes keratitis treatment | positively charged liposomes provided slow penetration of acyclovir through cornea and increase of its absorption [73] |
Tacrolimus-loaded liposomes containing bile salts | liposomes containing bile salts can increase the cornea permeability by 3–4 fold comparing with conventional liposomes containing cholesterol [62] |
Brinzolamide-loaded liposomes | high transmembrane permeation ability, improvement of the brinzolamide transport through cornea, effective and sustained interocular pressure reduction [64] |
Silk fibroin-coated ibuprofen-loaded liposomes | improvement of cell adhesion and uptake behaviors, Sustained drug release and high transcornea permeability, no cytotoxicity [65] |
thrombospondin-1-derived peptide, KRFK-loaded liposomes | transcornea permeability improvement [66] |
anionic liposomes for peptide and cDNA delivery | efficient peptide delivery to human cornea epithelial cells, modest while advantageous transfection of human cornea epithelial cells [67] |
deformable chitosan-coated flurbiprofen-loaded liposomes | easily moving across too small pores, precornea retention and ocular biocompatibility improvement [68] |
medroxyprogesterone acetate (MPA)-loaded liposomes | continuous sustained drug release without any side effects [69] |
fluconazole-loaded carbopol-integrated gel-core liposomes (carbosomes) | enhancing cornea permeability and long-term fluconazole delivery [74] |
azithromycin-cholesteryl hemisuccinate ion pair liposomes (ACIP-Lip) | improvement of entrapment efficiency and drug loading capacity by the use of ion pair method, continuous and pH-sensitive drug release [72] |
tetrodotoxin and dexmedetomidine-loaded modified succinyl-Concanavalin A liposomes | long period of analgesia, sustainable release of both tetrodotoxin and dexmedetomidine, modified liposomes were persisted on the surface of the cornea for long time duration [75] |
chitosan coated liposomes Triamcinolone Acetonide delivery | sustainable and reliable Triamcinolone Acetonide delivery, high drug encapsulation efficiency along with high positive surface charge [76] |
polyamidoamine dendrimer (PAMAM G3.0)-coated compound liposomes for berberine hydrochloride | enhancement of the bioavailability of berberine hydrochloride with no side effects [77] |
5.2. Dendrimers
5.3. Niosomes
- -
- The capacity for the entrapment of both hydrophilic and lipophilic drugs.
- -
- Providing drug administration in a sustained and controlled manner, as vesicles work as a storehouse.
- -
- Increasing the bioavailability of drugs.
- -
- Having a better stability compared to liposomes.
- -
- Osmotically active.
- -
- Nonimmunogenic to body.
5.4. Nanosuspensions
5.5. Hydrogels
6. Gene Therapy
7. Conclusions
Funding
Conflicts of Interest
References
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Mobaraki, M.; Soltani, M.; Zare Harofte, S.; L. Zoudani, E.; Daliri, R.; Aghamirsalim, M.; Raahemifar, K. Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review. Pharmaceutics 2020, 12, 1232. https://doi.org/10.3390/pharmaceutics12121232
Mobaraki M, Soltani M, Zare Harofte S, L. Zoudani E, Daliri R, Aghamirsalim M, Raahemifar K. Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review. Pharmaceutics. 2020; 12(12):1232. https://doi.org/10.3390/pharmaceutics12121232
Chicago/Turabian StyleMobaraki, Mohammadmahdi, Madjid Soltani, Samaneh Zare Harofte, Elham L. Zoudani, Roshanak Daliri, Mohamadreza Aghamirsalim, and Kaamran Raahemifar. 2020. "Biodegradable Nanoparticle for Cornea Drug Delivery: Focus Review" Pharmaceutics 12, no. 12: 1232. https://doi.org/10.3390/pharmaceutics12121232