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Micro-Injection Moulding of Poly(vinylpyrrolidone-vinyl acetate) Binary and Ternary Amorphous Solid Dispersions

1
Applied Polymer Technologies, Athlone Institute of Technology, Dublin Road, Athlone, N37 HD68 Co. Westmeath, Ireland
2
Synthesis and Solid State Pharmaceutical Centre (SSPC), Dublin Road, Athlone, N37 HD68 Co. Westmeath, Ireland
3
Materials Research Institute, Athlone Institute of Technology, Dublin Road, Athlone, N37 HD68 Co. Westmeath, Ireland
4
Faculty of Engineering and Informatics, Athlone Institute of Technology, Dublin Road, Athlone, N37 HD68 Co. Westmeath, Ireland
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(5), 240; https://doi.org/10.3390/pharmaceutics11050240
Received: 25 April 2019 / Revised: 14 May 2019 / Accepted: 15 May 2019 / Published: 18 May 2019
Micro-injection moulding (µIM) was used for the production of enteric tablets of plasticised and unplasticised solid dispersions of poly(vinylpyrrolidone-vinyl acetate) (PVPVA), and the effect of the mechanical and thermal treatment on the properties of the dispersions was investigated. The physical state of the systems showed to be unaltered by the µIM step, maintaining the drug in the amorphous state. The dissolution profile of the tablets showed a slower dissolution rate due to the lower surface to volume ratio compared to the extruded strands. The lack of solubility of the doses in the acidic medium as a consequence of the acidity of indomethacin (IND) was observed. However, in neutral pH the drug dissolution showed slower rates without affecting the dissolution extent, showing a potential application for the development of controlled release doses. Overall, the production of tablets of amorphous solid dispersions (ASD), coupling hot-melt extrusion (HME) and µIM, proved to be a successful approach towards a continuous automated manufacturing process to improve the aqueous solubility of poorly water-soluble drugs. View Full-Text
Keywords: amorphous solid dispersions; class II drugs; continuous processing; micro-injection moulding; indomethacin; poly(vinylpyrrolidone-vinyl acetate) amorphous solid dispersions; class II drugs; continuous processing; micro-injection moulding; indomethacin; poly(vinylpyrrolidone-vinyl acetate)
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MDPI and ACS Style

Pezzoli, R.; Hopkins Jnr, M.; Direur, G.; Gately, N.; Lyons, J.G.; Higginbotham, C.L. Micro-Injection Moulding of Poly(vinylpyrrolidone-vinyl acetate) Binary and Ternary Amorphous Solid Dispersions. Pharmaceutics 2019, 11, 240.

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