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Open AccessArticle

Enhanced Transepithelial Permeation of Gallic Acid and (−)-Epigallocatechin Gallate across Human Intestinal Caco-2 Cells Using Electrospun Xanthan Nanofibers

Nano-BioScience Research Group, DTU-Food, Technical University of Denmark, Kemitorvet, B202, 2800 Kgs. Lyngby, Denmark
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Pharmaceutics 2019, 11(4), 155; https://doi.org/10.3390/pharmaceutics11040155
Received: 17 December 2018 / Revised: 17 March 2019 / Accepted: 20 March 2019 / Published: 1 April 2019
(This article belongs to the Special Issue Electrospun and Electrosprayed Formulations for Drug Delivery)
Electrospun xanthan polysaccharide nanofibers (X) were developed as an encapsulation and delivery system of the poorly absorbed polyphenol compounds, gallic acid (GA) and (−)-epigallocatechin gallate (EGCG). Scanning electron microscopy was used to characterize the electrospun nanofibers, and controlled release studies were performed at pH 6.5 and 7.4 in saline buffer, suggesting that the release of polyphenols from xanthan nanofibers follows a non-Fickian mechanism. Furthermore, the X-GA and X-EGCG nanofibers were incubated with Caco-2 cells, and the cell viability, transepithelial transport, and permeability properties across cell monolayers were investigated. Increases of GA and EGCG permeabilities were observed when the polyphenols were loaded into xanthan nanofibers, compared to the free compounds. The observed in vitro permeability enhancement of GA and EGCG was induced by the presence of the polysaccharide nanofibers, which successfully inhibited efflux transporters, as well as by opening tight junctions. View Full-Text
Keywords: xanthan gum; electrospinning; gallic acid; (−)-epigallocatechin gallate; permeability xanthan gum; electrospinning; gallic acid; (−)-epigallocatechin gallate; permeability
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MDPI and ACS Style

Faralli, A.; Shekarforoush, E.; Mendes, A.C.; Chronakis, I.S. Enhanced Transepithelial Permeation of Gallic Acid and (−)-Epigallocatechin Gallate across Human Intestinal Caco-2 Cells Using Electrospun Xanthan Nanofibers. Pharmaceutics 2019, 11, 155. https://doi.org/10.3390/pharmaceutics11040155

AMA Style

Faralli A, Shekarforoush E, Mendes AC, Chronakis IS. Enhanced Transepithelial Permeation of Gallic Acid and (−)-Epigallocatechin Gallate across Human Intestinal Caco-2 Cells Using Electrospun Xanthan Nanofibers. Pharmaceutics. 2019; 11(4):155. https://doi.org/10.3390/pharmaceutics11040155

Chicago/Turabian Style

Faralli, Adele; Shekarforoush, Elhamalsadat; Mendes, Ana C.; Chronakis, Ioannis S. 2019. "Enhanced Transepithelial Permeation of Gallic Acid and (−)-Epigallocatechin Gallate across Human Intestinal Caco-2 Cells Using Electrospun Xanthan Nanofibers" Pharmaceutics 11, no. 4: 155. https://doi.org/10.3390/pharmaceutics11040155

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