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Article

3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology

1
Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK
2
FabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UK
3
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, R + D Pharma Group (GI-1645), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
*
Authors to whom correspondence should be addressed.
Pharmaceutics 2019, 11(4), 148; https://doi.org/10.3390/pharmaceutics11040148
Received: 3 February 2019 / Revised: 22 March 2019 / Accepted: 25 March 2019 / Published: 29 March 2019
(This article belongs to the Special Issue 3D Printing of Pharmaceuticals and Drug Delivery Devices)
Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that can be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to utilise SLS 3DP, for the first time, to produce small oral dosage forms with modified release properties. As such, paracetamol-loaded 3D printed multiparticulates, termed miniprintlets, were fabricated in 1 mm and 2 mm diameters. Despite their large surface area compared with a conventional monolithic tablet, the ethyl cellulose-based miniprintlets exhibited prolonged drug release patterns. The possibility of producing miniprintlets combining two drugs, namely paracetamol and ibuprofen, was also investigated. By varying the polymer, the dual miniprintlets were programmed to achieve customised drug release patterns, whereby one drug was released immediately from a Kollicoat Instant Release matrix, whilst the effect of the second drug was sustained over an extended time span using ethyl cellulose. Herein, this work has highlighted the versatility of SLS 3DP to fabricate small and intricate formulations containing multiple active pharmaceutical ingredients with distinct release properties. View Full-Text
Keywords: three dimensional printing; additive manufacturing; 3D printed drug products; printlets; personalised medicines; personalized pharmaceuticals; multiple units; spheroids; beads; acetaminophen three dimensional printing; additive manufacturing; 3D printed drug products; printlets; personalised medicines; personalized pharmaceuticals; multiple units; spheroids; beads; acetaminophen
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MDPI and ACS Style

Awad, A.; Fina, F.; Trenfield, S.J.; Patel, P.; Goyanes, A.; Gaisford, S.; Basit, A.W. 3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology. Pharmaceutics 2019, 11, 148. https://doi.org/10.3390/pharmaceutics11040148

AMA Style

Awad A, Fina F, Trenfield SJ, Patel P, Goyanes A, Gaisford S, Basit AW. 3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology. Pharmaceutics. 2019; 11(4):148. https://doi.org/10.3390/pharmaceutics11040148

Chicago/Turabian Style

Awad, Atheer; Fina, Fabrizio; Trenfield, Sarah J.; Patel, Pavanesh; Goyanes, Alvaro; Gaisford, Simon; Basit, Abdul W. 2019. "3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology" Pharmaceutics 11, no. 4: 148. https://doi.org/10.3390/pharmaceutics11040148

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