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Review

Gene Therapy Approaches to Functional Cure and Protection of Hematopoietic Potential in HIV Infection

Department of Immunology, Kindai University Faculty of Medicine, Osaka 5898511, Japan
Pharmaceutics 2019, 11(3), 114; https://doi.org/10.3390/pharmaceutics11030114
Received: 7 February 2019 / Revised: 5 March 2019 / Accepted: 6 March 2019 / Published: 11 March 2019
(This article belongs to the Special Issue Novel Approaches for Delivery of Anti-HIV Drugs)
Although current antiretroviral drug therapy can suppress the replication of human immunodeficiency virus (HIV), a lifelong prescription is necessary to avoid viral rebound. The problem of persistent and ineradicable viral reservoirs in HIV-infected people continues to be a global threat. In addition, some HIV-infected patients do not experience sufficient T-cell immune restoration despite being aviremic during treatment. This is likely due to altered hematopoietic potential. To achieve the global eradication of HIV disease, a cure is needed. To this end, tremendous efforts have been made in the field of anti-HIV gene therapy. This review will discuss the concepts of HIV cure and relative viral attenuation and provide an overview of various gene therapy approaches aimed at a complete or functional HIV cure and protection of hematopoietic functions. View Full-Text
Keywords: human immunodeficiency virus; acquired immunodeficiency syndrome; hematopoietic stem/progenitor cells; gene therapy human immunodeficiency virus; acquired immunodeficiency syndrome; hematopoietic stem/progenitor cells; gene therapy
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MDPI and ACS Style

Tsukamoto, T. Gene Therapy Approaches to Functional Cure and Protection of Hematopoietic Potential in HIV Infection. Pharmaceutics 2019, 11, 114. https://doi.org/10.3390/pharmaceutics11030114

AMA Style

Tsukamoto T. Gene Therapy Approaches to Functional Cure and Protection of Hematopoietic Potential in HIV Infection. Pharmaceutics. 2019; 11(3):114. https://doi.org/10.3390/pharmaceutics11030114

Chicago/Turabian Style

Tsukamoto, Tetsuo. 2019. "Gene Therapy Approaches to Functional Cure and Protection of Hematopoietic Potential in HIV Infection" Pharmaceutics 11, no. 3: 114. https://doi.org/10.3390/pharmaceutics11030114

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