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Article

Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques

1
Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudosok krt. 2., H-1117 Budapest, Hungary
2
Research Institute of Biomolecular and Chemical Engineering, University of Pannonia, Egyetem u. 2., H-8200 Veszprém, Hungary
3
Department of Medicine 1, University Hospital Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany
4
Department of Radiotherapy and Oncology, University Hospital Frankfurt am Main, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany
5
Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt, Germany
6
Department of Pharmacy, National University of Singapore, 6 Science Drive 2, Singapore 117546, Singapore
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(10), 489; https://doi.org/10.3390/pharmaceutics11100489
Received: 15 August 2019 / Revised: 6 September 2019 / Accepted: 18 September 2019 / Published: 23 September 2019
(This article belongs to the Special Issue PLGA Based Drug Carrier and Pharmaceutical Applications)
Today, efficient delivery of sorafenib to hepatocellular carcinoma remains a challenge for current drug formulation strategies. Incorporating the lipophilic molecule into biocompatible and biodegradable theranostic nanocarriers has great potential for improving the efficacy and safety of cancer therapy. In the present study, three different technologies for the encapsulation of sorafenib into poly(d,l-lactide-co-glycolide) and polyethylene glycol-poly(d,l-lactide-co-glycolide) copolymers were compared. The particles ranged in size between 220 and 240 nm, with encapsulation efficiencies from 76.1 ± 1.7% to 69.1 ± 10.1%. A remarkable maximum drug load of approximately 9.0% was achieved. Finally, a gadolinium complex was covalently attached to the nanoparticle surface, transforming the nanospheres into theranostic devices, allowing their localization using magnetic resonance imaging. The manufacture of sorafenib-loaded nanoparticles alongside the functionalization of the particle surface with gadolinium complexes resulted in a highly efficacious nanodelivery system which exhibited a strong magnetic resonance imaging signal, optimal stability features, and a sustained release profile. View Full-Text
Keywords: gadolinium; drug release; polymeric nanocarrier; sorafenib; theranostic nanoparticles gadolinium; drug release; polymeric nanocarrier; sorafenib; theranostic nanoparticles
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MDPI and ACS Style

Feczkó, T.; Piiper, A.; Pleli, T.; Schmithals, C.; Denk, D.; Hehlgans, S.; Rödel, F.; Vogl, T.J.; Wacker, M.G. Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques. Pharmaceutics 2019, 11, 489. https://doi.org/10.3390/pharmaceutics11100489

AMA Style

Feczkó T, Piiper A, Pleli T, Schmithals C, Denk D, Hehlgans S, Rödel F, Vogl TJ, Wacker MG. Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques. Pharmaceutics. 2019; 11(10):489. https://doi.org/10.3390/pharmaceutics11100489

Chicago/Turabian Style

Feczkó, Tivadar, Albrecht Piiper, Thomas Pleli, Christian Schmithals, Dominic Denk, Stephanie Hehlgans, Franz Rödel, Thomas J. Vogl, and Matthias G. Wacker. 2019. "Theranostic Sorafenib-Loaded Polymeric Nanocarriers Manufactured by Enhanced Gadolinium Conjugation Techniques" Pharmaceutics 11, no. 10: 489. https://doi.org/10.3390/pharmaceutics11100489

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