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Electrospinning of Cyclodextrin Functional Nanofibers for Drug Delivery Applications

by * and *
Institute of Materials Science & Nanotechnology, UNAM-National Nanotechnology Research Center, Bilkent University, 06800 Ankara, Turkey
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Authors to whom correspondence should be addressed.
Pharmaceutics 2019, 11(1), 6; https://doi.org/10.3390/pharmaceutics11010006
Received: 11 July 2018 / Revised: 17 August 2018 / Accepted: 24 August 2018 / Published: 24 December 2018
(This article belongs to the Special Issue Electrospun and Electrosprayed Formulations for Drug Delivery)
Electrospun nanofibers have sparked tremendous attention in drug delivery since they can offer high specific surface area, tailored release of drugs, controlled surface chemistry for preferred protein adsorption, and tunable porosity. Several functional motifs were incorporated into electrospun nanofibers to greatly expand their drug loading capacity or to provide the sustained release of the embedded drug molecules. In this regard, cyclodextrins (CyD) are considered as ideal drug carrier molecules as they are natural, edible, and biocompatible compounds with a truncated cone-shape with a relatively hydrophobic cavity interior for complexation with hydrophobic drugs and a hydrophilic exterior to increase the water-solubility of drugs. Further, the formation of CyD-drug inclusion complexes can protect drug molecules from physiological degradation, or elimination and thus increases the stability and bioavailability of drugs, of which the release takes place with time, accompanied by fiber degradation. In this review, we summarize studies related to CyD-functional electrospun nanofibers for drug delivery applications. The review begins with an introductory description of electrospinning; the structure, properties, and toxicology of CyD; and CyD-drug complexation. Thereafter, the release of various drug molecules from CyD-functional electrospun nanofibers is provided in subsequent sections. The review concludes with a summary and outlook on material strategies. View Full-Text
Keywords: cyclodextrin; electrospinning; drug delivery; nanofibers; cyclodextrin-inclusion complexes; essential oils; electrospun nanofibers; poly-cyclodextrin; antibacterial; antibiotics cyclodextrin; electrospinning; drug delivery; nanofibers; cyclodextrin-inclusion complexes; essential oils; electrospun nanofibers; poly-cyclodextrin; antibacterial; antibiotics
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MDPI and ACS Style

Topuz, F.; Uyar, T. Electrospinning of Cyclodextrin Functional Nanofibers for Drug Delivery Applications. Pharmaceutics 2019, 11, 6. https://doi.org/10.3390/pharmaceutics11010006

AMA Style

Topuz F, Uyar T. Electrospinning of Cyclodextrin Functional Nanofibers for Drug Delivery Applications. Pharmaceutics. 2019; 11(1):6. https://doi.org/10.3390/pharmaceutics11010006

Chicago/Turabian Style

Topuz, Fuat; Uyar, Tamer. 2019. "Electrospinning of Cyclodextrin Functional Nanofibers for Drug Delivery Applications" Pharmaceutics 11, no. 1: 6. https://doi.org/10.3390/pharmaceutics11010006

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