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Magnetic Mixed Micelles Composed of a Non-Ionic Surfactant and Nitroxide Radicals Containing a d-Glucosamine Unit: Preparation, Stability, and Biomedical Application

1
Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan
2
Department of Obstetrics and Gynecology, Shiga University of Medical Science, Shiga 520-2192, Japan
3
Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow 119991, Russian Federation
4
Graduate School of Informatics, Kyoto University, Kyoto 606-8501, Japan
*
Authors to whom correspondence should be addressed.
These authors should be addressed as co-first author.
Pharmaceutics 2019, 11(1), 42; https://doi.org/10.3390/pharmaceutics11010042
Received: 5 December 2018 / Revised: 5 January 2019 / Accepted: 9 January 2019 / Published: 19 January 2019
(This article belongs to the Special Issue Nanotheranostics and Cancer: Where Are We Now?)
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Abstract

Metal-free magnetic mixed micelles (mean diameter: < 20 nm) were prepared by mixing the biocompatible non-ionic surfactant Tween 80 and the non-toxic, hydrophobic pyrrolidine-N-oxyl radicals bearing a d-glucosamine unit in pH 7.4 phosphate-buffered saline (PBS). The time-course stability and in vitro magnetic resonance imaging (MRI) contrast ability of the mixed micelles was found to depend on the length of the alkyl chain in the nitroxide radicals. It was also confirmed that the mixed micelles exhibited no toxicity in vivo and in vitro and high stability in the presence of a large excess of ascorbic acid. The in vivo MRI experiment revealed that one of these mixed micelles showed much higher contrast enhancement in the proton longitudinal relaxation time (T1) weighted images than other magnetic mixed micelles that we have reported previously. Thus, the magnetic mixed micelles presented here are expected to serve as a promising contrast agent for theranostic nanomedicines, such as MRI-visible targeted drug delivery carriers. View Full-Text
Keywords: nitroxide radical; magnetic resonance imaging; glucosamine; cancer; micelle nitroxide radical; magnetic resonance imaging; glucosamine; cancer; micelle
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Nagura, K.; Takemoto, Y.; Yoshino, F.; Bogdanov, A.; Chumakova, N.; Vorobiev, A.K.; Imai, H.; Matsuda, T.; Shimono, S.; Kato, T.; Komatsu, N.; Tamura, R. Magnetic Mixed Micelles Composed of a Non-Ionic Surfactant and Nitroxide Radicals Containing a d-Glucosamine Unit: Preparation, Stability, and Biomedical Application. Pharmaceutics 2019, 11, 42.

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