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Pharmaceutics
Volume 11
Issue 1
10.3390/pharmaceutics11010013
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Open AccessArticle

Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress

by
Maryam Rezvani
1,2,
Maria Letizia Manca
1,*,
Carla Caddeo
1,
Elvira Escribano-Ferrer
3,
Claudia Carbone
4,
José Esteban Peris
5,
Iris Usach
5,
Octavio Diez-Sales
5,6,
Anna Maria Fadda
1 and
Maria Manconi
1
1
Department of Scienze della Vita e dell’Ambiente, University of Cagliari, via Ospedale 72, 09124 Cagliari, Italy
2
Department of Food Science and Technology, Faculty of Agriculture, University of Tabriz, 51666-16471 Tabriz, Iran
3
Department of Pharmacy and Pharmaceutical Technology and Physical-Chemistry, Faculty of Pharmacy and Food Science, Institut of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain
4
Department of Scienze del Farmaco, University of Catania, Viale A. Doria 6, 95125 Catania, Italy
5
Department of Pharmacy, Pharmaceutical Technology and Parasitology, University of Valencia, Avda Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain
6
Instituto de Reconocimiento Molecular y Desarrollo Tecnológico, Centro Mixto Universidad Politécnica de Valencia, Universidad de Valencia, Avda Vicente Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain
*
Author to whom correspondence should be addressed.
Pharmaceutics 2019, 11(1), 13; https://doi.org/10.3390/pharmaceutics11010013
Received: 6 December 2018 / Revised: 17 December 2018 / Accepted: 28 December 2018 / Published: 4 January 2019
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Abstract

The present study aimed at developing a new vesicular formulation capable of promoting the protective effect of ascorbic acid and tocopherol against intestinal oxidative stress damage, and their efficacy in intestinal wound healing upon oral administration. A pH-dependent copolymer (Eudragit® L100), a water-soluble prebiotic fibre (Nutriose® FM06), a phospholipid mixture (Lipoid S75), and two natural antioxidants (ascorbic acid and tocopherol) were combined to fabricate eudragit-nutriosomes by a simple, solvent-free procedure. The vesicles were spherical and oligolamellar, with some multicompartment structures in Eudragit-nutriosomes, small in size (~100 nm), with highly negative zeta potential. The effect of Eudragit® and Nutriose® on the stability on storage and in simulated gastrointestinal fluids were confirmed by the Turbiscan® technology and in vitro studies, respectively. Eudragit-nutriosomes exhibited a protective effect against H2O2-induced oxidative stress, and a proliferative effect in Caco-2 cells, as they provided the closure of the scratched area after 96 h of incubation. View Full-Text
Keywords: Eudragit; Nutriose; phospholipid vesicles; antioxidant; intestinal wound healing Eudragit; Nutriose; phospholipid vesicles; antioxidant; intestinal wound healing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style

Rezvani, M.; Manca, M.L.; Caddeo, C.; Escribano-Ferrer, E.; Carbone, C.; Peris, J.E.; Usach, I.; Diez-Sales, O.; Fadda, A.M.; Manconi, M. Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress. Pharmaceutics 2019, 11, 13. https://doi.org/10.3390/pharmaceutics11010013

AMA Style

Rezvani M, Manca ML, Caddeo C, Escribano-Ferrer E, Carbone C, Peris JE, Usach I, Diez-Sales O, Fadda AM, Manconi M. Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress. Pharmaceutics. 2019; 11(1):13. https://doi.org/10.3390/pharmaceutics11010013

Chicago/Turabian Style

Rezvani, Maryam; Manca, Maria L.; Caddeo, Carla; Escribano-Ferrer, Elvira; Carbone, Claudia; Peris, José E.; Usach, Iris; Diez-Sales, Octavio; Fadda, Anna M.; Manconi, Maria. 2019. "Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress" Pharmaceutics 11, no. 1: 13. https://doi.org/10.3390/pharmaceutics11010013

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